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発表論文

• 2024年
• 2023年
• 2022年
• 2021年
• 2020年
• 2019年
• 2018年
• 2017年
• 2016年
• 2015年
• 2014年
• 2013年

2024年

1. Saito R, Fujii T, Murata K, Onishi A, Murakami K, Tanaka M, Ohmura K, Yasuda T, Morinobu A, Matsuda S. Prediction models incorporating second metacarpal cortical index for osteoporosis in rheumatoid arthritis: Externally validated machine learning models developed using data from the KURAMA cohort. Int J Rheum Dis. 2024 Oct;27(10):e15358. doi: 10.1111/1756-185X.15358. PMID: 39373344.
2. Honda S, Murata K, Otsuki B, Shimizu T, Sono T, Masuda S, Shima K, Sakamoto M, Fujii T, Onishi A, Murakami K, Onizawa H, Tanaka M, Morinobu A, Matsuda S. Active Rheumatoid Arthritis and Scoliosis: A Mid-Term Cohort Study. Spine (Phila Pa 1976). 2024 May 15. doi: 10.1097/BRS.0000000000005035. Epub ahead of print. PMID: 38747218.
   • 関節リウマチ患者さんでは疾患活動性が悪いほど脊椎側弯が進行しやすいことがわかりました。
3. Fujii T, Murata K, Onizawa H, Onishi A, Murakami K, Tanaka M, Furu M, Ito H, Morinobu A, Matsuda S. The influence of medial cuneiform inclination on postoperative hallux valgus recurrence in rheumatoid arthritis patients: Insights from the KURAMA cohort study. Int J Rheum Dis. 2024 May;27(5):e15168. doi: 10.1111/1756-185X.15168. PMID: 38720579.
   • 足根骨の形態により、関節リウマチ患者では外反母趾の術後再発率に差があることがわかりました。
4. Umeda A, Murata K, Murotani Y, Fujii T, Onishi A, Murakami K, Onizawa H, Otsuki B, Shimizu T, Tanaka M, Morinobu A, Matsuda S. Low Hounsfield unit values on computed tomography as a potential predictor of vertebral fracture in patients with rheumatoid arthritis: The KURAMA cohort study. Int J Rheum Dis. 2024 Apr;27(4):e15146. doi: 10.1111/1756-185X.15146. PMID: 38661342.
   • 関節リウマチの患者さんでは、脊椎圧迫骨折の発症率が高い群が胸部CTから予測できることがわかりました。
5. Murata K, Uozumi R, Fujii T, Onishi A, Murakami K, Onizawa H, Tanaka M, Morinobu A, Matsuda S. Effects of IL-6, JAK, TNF inhibitors, and CTLA4-Ig on knee symptoms in patients with rheumatoid arthritis. Sci Rep. 2024 Jul 2;14(1):15226. doi: 10.1038/s41598-024-66064-3. PMID: 38956271; PMCID: PMC11220105.
   • 生物学的製剤・JAK阻害薬の膝関節症状に対する効果に違いがあることがわかりました。
6. Iwasaki T, Watanabe R, Ito H, Fujii T, Ohmura K, Yoshitomi H, Murata K, Murakami K, Onishi A, Tanaka M, Matsuda S, Matsuda F, Morinobu A, Hashimoto M. Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis. Arthritis Res Ther. 2024 Jan 2;26(1):1. doi: 10.1186/s13075-023-03236-y. PMID: 38167328; PMCID: PMC10759752.
   • 生物学的製剤アバタセプト治療を受けた患者さんにおいて、治療前に血液細胞の一種、単球の割合が高かった方、および血液細胞のmRNA中に単球由来の遺伝子が多かった方は、アバタセプトの治療成績が劣る可能性があることが示されました。
7. Fujii T, Murata K, Onizawa H, Onishi A, Tanaka M, Murakami K, Nishitani K, Furu M, Watanabe R, Hashimoto M, Ito H, Fujii T, Mimori T, Morinobu A, Matsuda S. Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort. Arthritis Res Ther. 2024 Jan 9;26(1):16. doi: 10.1186/s13075-023-03251-z. PMID: 38195572; PMCID: PMC10775516.
   • KURAMAコホート10年間の治療成績の変遷をまとめました。生物学的製剤、JAK阻害薬の治療を受けている患者さんの割合が徐々に増加し、5割を超えた一方、ステロイドで加療されている方の割合は減少し、最近では2割を下回っていました。それに伴い、治療成績は年々向上していることがわかりました。
8. Kawakami T, Masui S, Onishi A, Onizawa H, Fujii T, Murakami K, Murata K, Tanaka M, Shimada T, Nakagawa S, Matsuda S, Morinobu A, Terada T, Yonezawa A. Comparison of safety and effectiveness between etanercept biosimilar LBEC0101 and reference in patients with rheumatoid arthritis in real-world data using the KURAMA cohort. Mod Rheumatol. 2024 Mar 5:roae018. doi: 10.1093/mr/roae018. Epub ahead of print. PMID: 38516944.
   • 生物学的製剤エタネルセプト（エンブレル®）とエタネルセプトのバイオシミラーの血中濃度に明らかな差はなく、有効性も同等でした。
9. Honda S, Murata K, Fujibayashi S, Otsuki B, Shimizu T, Fujii T, Okuzu Y, Kawai T, Kuroda Y, Onishi A, Murakami K, Onizawa H, Tanaka M, Morinobu A, Matsuda S. Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis. J Neurosurg Spine. 2024 Mar 29:1-9. doi: 10.3171/2024.1.SPINE231199. Epub ahead of print. PMID: 38552241.
   • 脊椎全体の前後方向のバランスが、関節リウマチ患者では徐々に悪くなる傾向があり、とくに関節リウマチの疾患活動性が悪いと、バランスが悪くなりやすいということがわかりました。

2023年

1. Ebina K, Hirano T, Maeda Y, Okita Y, Etani Y, Hirao M, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Kotani T, Shiba H, Katayama M, Yamamoto K, Kumanogoh A, Okada S, Nakata K. Add-on effectiveness of methotrexate or iguratimod in patients with rheumatoid arthritis exhibiting an inadequate response to Janus kinase inhibitors: The ANSWER cohort study. Mod Rheumatol. 2023 Jul 4;33(4):690-699. doi: 10.1093/mr/roac092. PMID: 35962543.
2. Ebina K, Etani Y, Maeda Y, Okita Y, Hirao M, Yamamoto W, Hashimoto M, Murata K, Hara R, Nagai K, Hiramatsu Y, Son Y, Amuro H, Fujii T, Okano T, Ueda Y, Katayama M, Okano T, Tachibana S, Hayashi S, Kumanogoh A, Okada S, Nakata K. Drug retention of biologics and Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study. RMD Open. 2023 Aug;9(3):e003160. doi: 10.1136/rmdopen-2023-003160. PMID: 37597846; PMCID: PMC10441119.
3. Fujii T, Murata K, Onizawa H, Onishi A, Tanaka M, Murakami K, Nishitani K, Furu M, Watanabe R, Hashimoto M, Ito H, Fujii T, Mimori T, Morinobu A, Matsuda S. Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort. Arthritis Res Ther. 2024 Jan 9;26(1):16. doi: 10.1186/s13075-023-03251-z. PMID: 38195572; PMCID: PMC10775516.
4. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. PMID: 36948555; PMCID: PMC10040075.
5. Hayashi S, Tachibana S, Maeda T, Yamashita M, Shirasugi I, Yamamoto Y, Yamada H, Okano T, Nishimura K, Ueda Y, Jinnno S, Saegusa J, Yamamoto W, Murata K, Fujii T, Hata K, Yoshikawa A, Ebina K, Etani Y, Yoshida N, Amuro H, Hashimoto M, Hara R, Katayama M, Okano T, Kuroda R. Real-world comparative study of the efficacy of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study. Rheumatology (Oxford). 2023 Nov 1:kead543. doi: 10.1093/rheumatology/kead543. Epub ahead of print. Erratum in: Rheumatology (Oxford). 2024 Feb 13:keae095. doi: 10.1093/rheumatology/keae095. PMID: 37924201.
6. Iwasaki T, Watanabe R, Ito H, Fujii T, Ohmura K, Yoshitomi H, Murata K, Murakami K, Onishi A, Tanaka M, Matsuda S, Matsuda F, Morinobu A, Hashimoto M. Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis. Arthritis Res Ther. 2024 Jan 2;26(1):1. doi: 10.1186/s13075-023-03236-y. PMID: 38167328; PMCID: PMC10759752.
7. Jinno S, Onishi A, Hattori S, Dubreuil M, Ueda Y, Nishimura K, Okano T, Yamada H, Yamamoto W, Murata K, Onizawa H, Ebina K, Maeda Y, Son Y, Amuro H, Hara R, Hata K, Shiba H, Katayama M, Watanabe R, Hashimoto M, Saegusa J. Comparison of retention of biologics in Japanese patients with elderly-onset rheumatoid arthritis-the ANSWER cohort study. Rheumatology (Oxford). 2024 Feb 6:keae081. doi: 10.1093/rheumatology/keae081. Epub ahead of print. PMID: 38317442.
8. Katsushima M, Minamino H, Shirakashi M, Onishi A, Fujita Y, Yamamoto W, Onizawa H, Tsuji H, Watanabe R, Murakami K, Fujii T, Murata K, Tanaka M, Inagaki N, Morinobu A, Hashimoto M. High plasma homocysteine level is associated with increased prevalence of the non-remission state in rheumatoid arthritis: Findings from the KURAMA cohort. Mod Rheumatol. 2023 Aug 25;33(5):911-917. doi: 10.1093/mr/roac106. PMID: 36069659.
9. Masuda S, Fukasawa T, Takeuchi M, Fujibayashi S, Otsuki B, Murata K, Shimizu T, Matsuda S, Kawakami K. Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study. Clin Orthop Relat Res. 2023 Jan 1;481(1):145-154. doi: 10.1097/CORR.0000000000002322. Epub 2022 Jul 15. Erratum in: Clin Orthop Relat Res. 2024 Mar 1;482(3):569. doi: 10.1097/CORR.0000000000002982. PMID: 35838602; PMCID: PMC9750527.
10. Masui S, Yonezawa A, Nakamura M, Onishi A, Hashimoto M, Onizawa H, Fujii T, Murakami K, Murata K, Tanaka M, Yokoyama K, Iwamoto N, Shimada T, Itohara K, Hira D, Nakagawa S, Imai S, Nakagawa T, Hayakari M, Matsuda S, Morinobu A, Terada T, Matsubara K. Serum Concentrations of Infliximab and IL-6 for Predicting One-Year Discontinuation of Infliximab Treatment Owing to Secondary Non-response in Patients with Rheumatoid Arthritis. Biol Pharm Bull. 2023;46(8):1112-1119. doi: 10.1248/bpb.b23-00192. PMID: 37532562.
11. Mukoyama H, Murakami K, Onizawa H, Shirakashi M, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Nakashima R, Onishi A, Yoshifuji H, Tanaka M, Morinobu A. A case of atypical IgG4-related disease presenting hypereosinophilia, polyneuropathy, and liver dysfunction. Mod Rheumatol Case Rep. 2023 Dec 29;8(1):172-177. doi: 10.1093/mrcr/rxad053. Erratum in: Mod Rheumatol Case Rep. 2023 Dec 01:rxad066. doi: 10.1093/mrcr/rxad066. PMID: 37750557.
12. Mukoyama H, Murakami K, Onizawa H, Shirakashi M, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Nakashima R, Onishi A, Yoshifuji H, Tanaka M, Morinobu A. A case of atypical IgG4-related disease presenting hypereosinophilia, polyneuropathy, and liver dysfunction. Mod Rheumatol Case Rep. 2023 Dec 29;8(1):172-177. doi: 10.1093/mrcr/rxad053. Erratum in: Mod Rheumatol Case Rep. 2023 Dec 01:rxad066. doi: 10.1093/mrcr/rxad066. PMID: 37750557.
13. Nakajima T, Doi H, Watanabe R, Murata K, Takase Y, Inaba R, Itaya T, Iwasaki T, Shirakashi M, Tsuji H, Kitagori K, Akizuki S, Nakashima R, Onishi A, Yoshifuji H, Tanaka M, Ito H, Hashimoto M, Ohmura K, Morinobu A. Factors associated with osteoporosis and fractures in patients with systemic lupus erythematosus: Kyoto Lupus Cohort. Mod Rheumatol. 2023 Dec 22;34(1):113-121. doi: 10.1093/mr/road014. PMID: 36680424.
14. Nakayama Y, Watanabe R, Yamamoto W, Ebina K, Hirano T, Kotani T, Shiba H, Katayama M, Son Y, Amuro H, Onishi A, Jinno S, Hara R, Murakami K, Murata K, Ito H, Tanaka M, Matsuda S, Morinobu A, Hashimoto M. IL-6 inhibitors and JAK inhibitors as favourable treatment options for patients with anaemia and rheumatoid arthritis: ANSWER cohort study. Rheumatology (Oxford). 2024 Feb 1;63(2):349-357. doi: 10.1093/rheumatology/kead299. PMID: 37354495.
15. Nishida Y, Shirakashi M, Hashii N, Nakashima R, Nakayama Y, Katsushima M, Watanabe R, Onizawa H, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Onishi A, Murakami K, Yoshifuji H, Tanaka M, Tsuruyama T, Morinobu A, Hashimoto M. Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus. Mod Rheumatol. 2024 Mar 28;34(3):523-529. doi: 10.1093/mr/road054. PMID: 37300805.
16. Noguchi T, Sakamoto A, Murotani Y, Murata K, Hirata M, Yamada Y, Toguchida J, Matsuda S. Inhibition of RANKL Expression in Osteocyte-like Differentiated Tumor Cells in Giant Cell Tumor of Bone After Denosumab Treatment. J Histochem Cytochem. 2023 Mar;71(3):131-138. doi: 10.1369/00221554231163638. Epub 2023 Mar 27. PMID: 36971322; PMCID: PMC10084568.
17. Onishi A, Kaizu M, Shirasugi I, Yagyu T, Ueda Y, Sakai Y, Miura Y, Saegusa J. Demographic, Physical, and Psychological Determinants of Patient Experience with Subcutaneous Self-Injection in Patients with Rheumatoid Arthritis: Structural Equation Modeling Approach. Patient Prefer Adherence. 2023 Jul 3;17:1551-1559. doi: 10.2147/PPA.S413871. PMID: 37426046; PMCID: PMC10327901.
18. Onishi A, Torii M, Hidaka Y, Uozumi R, Oshima Y, Tanaka H, Onizawa H, Fujii T, Murata K, Murakami K, Tanaka M, Matsuda S, Morinobu A, Arai H, Hashimoto M. Efficacy of personalized exercise program on physical function in elderly patients with rheumatoid arthritis at high risk for sarcopenia: study protocol for a randomized controlled trial. BMC Musculoskelet Disord. 2023 Apr 11;24(1):280. doi: 10.1186/s12891-023-06185-4. PMID: 37041556; PMCID: PMC10088120.
19. Onishi A, Tsuji H, Takase Y, Nakakubo Y, Iwasaki T, Kozuki T, Yoshida T, Shirakashi M, Onizawa H, Hiwa R, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Morinobu A. Comparisons of SLE-DAS and SLEDAI-2K and classification of disease activity based on the SLE-DAS with reference to patient-reported outcomes. Rheumatology (Oxford). 2023 Dec 1;62(12):3909-3915. doi: 10.1093/rheumatology/kead132. PMID: 36943365.
20. Shiba H, Kotani T, Nagai K, Hata K, Yamamoto W, Yoshikawa A, Wada Y, Hiramatsu Y, Makino H, Ueda Y, Onishi A, Murata K, Amuro H, Son Y, Hara R, Hirano T, Ebina K, Katayama M, Hashimoto M, Takeuchi T. Prognostic Factors Affecting Death in Patients with Rheumatoid Arthritis Complicated by Pneumocystis jirovecii Pneumonia and One-Year Clinical Course: The ANSWER Cohort Study. Int J Mol Sci. 2023 Apr 17;24(8):7399. doi: 10.3390/ijms24087399. PMID: 37108561; PMCID: PMC10138913.
21. Shirata M, Ito I, Tanaka M, Murata K, Murakami K, Ikeda H, Oi I, Hamao N, Nishioka K, Hayashi Y, Nagao M, Hashimoto M, Ito H, Ueno H, Morinobu A, Hirai T. Impact of methotrexate on humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis. Clin Exp Med. 2023 Dec;23(8):4707-4720. doi: 10.1007/s10238-023-01163-5. Epub 2023 Aug 16. PMID: 37582911.
22. Tajika A, Tsujimoto Y, Onishi A, Tsutsumi Y, Funada S, Ogawa Y, Takeshima N, Hayasaka Y, Iwakami N, Furukawa TA. Twenty-year follow-up of promising clinical studies reported in highly circulated newspapers: a meta-epidemiological study. BMJ Health Care Inform. 2023 Jun;30(1):e100768. doi: 10.1136/bmjhci-2023-100768. PMID: 37316250; PMCID: PMC10277065.
23. Takase Y, Shirakashi M, Nishida Y, Katsushima M, Onizawa H, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Onishi A, Nakashima R, Murakami K, Yoshifuji H, Tanaka M, Tsuruyama T, Morinobu A, Hashimoto M. Enteric Toll-like receptor 7 stimulation causes acute exacerbation in lupus-susceptible mice. Clin Rheumatol. 2023 Apr;42(4):1185-1194. doi: 10.1007/s10067-022-06467-7. Epub 2022 Dec 14. PMID: 36515794.
24. Umemoto A, Ito H, Azukizawa M, Murata K, Tanaka M, Fujii T, Onishi A, Onizawa H, Ishie S, Murakami A, Nishitani K, Murakami K, Yoshitomi H, Hashimoto M, Morinobu A, Matsuda S. How do symptoms of each joint contribute to global pain, disease activity and functional disability in rheumatoid arthritis?-A comprehensive association study using a large cohort. PLoS One. 2023 Aug 25;18(8):e0285227. doi: 10.1371/journal.pone.0285227. PMID: 37624815; PMCID: PMC10456163.
25. Umemoto A, Kuwada T, Murata K, Shiokawa M, Ota S, Murotani Y, Itamoto A, Nishitani K, Yoshitomi H, Fujii T, Onishi A, Onizawa H, Murakami K, Tanaka M, Ito H, Seno H, Morinobu A, Matsuda S. Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2023 Feb 17;25(1):25. doi: 10.1186/s13075-023-03007-9. PMID: 36804906; PMCID: PMC9936655.
26. Watanabe R, Kadoba K, Tamamoto A, Murata K, Murakami K, Onizawa H, Fujii T, Onishi A, Tanaka M, Ito H, Morinobu A, Hashimoto M. CD8⁺ Regulatory T Cell Deficiency in Elderly-Onset Rheumatoid Arthritis. J Clin Med. 2023 Mar 17;12(6):2342. doi: 10.3390/jcm12062342. PMID: 36983342; PMCID: PMC10054757.
27. Watanabe R, Murakami K, Fujisaki T, Ito H, Murata K, Yamamoto W, Fujii T, Onizawa H, Onishi A, Tanaka M, Morinobu A, Hashimoto M. Baseline erythrocyte sedimentation rate level predicts long-term inhibition of radiographic progression by tocilizumab: the KURAMA cohort. Immunol Med. 2023 Jun;46(2):84-92. doi: 10.1080/25785826.2023.2170384. Epub 2023 Jan 23. PMID: 36688476.
28. Yamada H, Jinno S, Maeda T, Hayashi S, Yamamoto W, Onishi A, Onizawa H, Takeuchi T, Hiramatsu Y, Okita Y, Ebina K, Son Y, Yoshida N, Watanabe R, Hara R, Yamashita M, Nose Y, Yamamoto Y, Okano T, Nishimura K, Ueda Y, Sendo S, Hashimoto M, Kuroda R, Saegusa J. Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021: the ANSWER cohort study. Rheumatology (Oxford). 2024 Aug 1;63(8):2147-2151. doi: 10.1093/rheumatology/kead539. PMID: 37792494.
29. Yamaguchi E, Kadoba K, Watanabe R, Iwasaki T, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Morinobu A, Yoshifuji H. Clinical profile and outcome of large-vessel giant cell arteritis in Japanese patients: A single-centre retrospective cohort study. Mod Rheumatol. 2023 Jan 3;33(1):175-181. doi: 10.1093/mr/roac013. PMID: 35141755.
30. Yoshida S, Nishitani K, Yoshitomi H, Kuriyama S, Nakamura S, Fujii T, Saito M, Kobori Y, Murakami A, Murata K, Ito H, Ueno H, Matsuda S. Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2. Arthritis Rheumatol. 2023 Jun;75(6):950-960. doi: 10.1002/art.42424. Epub 2023 Mar 9. PMID: 36530127.
31. Zhang S, Tsuji H, Jin H, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Arase H, Ohmura K, Morinobu A. Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules. Rheumatology (Oxford). 2023 Sep 1;62(9):3151-3155. doi: 10.1093/rheumatology/kead024. PMID: 36645239.

2022年

1. Umemoto A, Kuwada T, Murata K, Shiokawa M, Ota S, Murotani Y, Itamoto A, Nishitani K, Yoshitomi H, Fujii T, Onishi A, Onizawa H, Murakami K, Tanaka M, Ito H, Seno H, Morinobu A, Matsuda S. Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2023 Feb 17;25(1):25. doi: 10.1186/s13075-023-03007-9. PMID: 36804906; PMCID: PMC9936655.
2. Watanabe R, Murakami K, Fujisaki T, Ito H, Murata K, Yamamoto W, Fujii T, Onizawa H, Onishi A, Tanaka M, Morinobu A, Hashimoto M. Baseline erythrocyte sedimentation rate level predicts long-term inhibition of radiographic progression by tocilizumab: the KURAMA cohort. Immunol Med. 2023 Jun;46(2):84-92. doi: 10.1080/25785826.2023.2170384. Epub 2023 Jan 23. PMID: 36688476.
3. Zhang S, Tsuji H, Jin H, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Arase H, Ohmura K, Morinobu A. Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules. Rheumatology (Oxford). 2023 Sep 1;62(9):3151-3155. doi: 10.1093/rheumatology/kead024. PMID: 36645239.
4. Yamaguchi E, Kadoba K, Watanabe R, Iwasaki T, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Morinobu A, Yoshifuji H. Clinical profile and outcome of large-vessel giant cell arteritis in Japanese patients: A single-centre retrospective cohort study. Mod Rheumatol. 2023 Jan 3;33(1):175-181. doi: 10.1093/mr/roac013. PMID: 35141755.
5. Tsuji H, Kuramoto N, Sasai T, Shirakashi M, Onizawa H, Kitagori K, Akizuki S, Nakashima R, Watanabe R, Onishi A, Murakami K, Yoshifuji H, Tanaka M, Hashimoto M, Ohmura K, Morinobu A. Autoantibody profiles associated with morbidity and mortality in scleroderma renal crisis. Rheumatology (Oxford). 2022 Oct 6;61(10):4130-4135. doi: 10.1093/rheumatology/keac047. PMID: 35078211.
6. Takase Y, Shirakashi M, Nishida Y, Katsushima M, Onizawa H, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Onishi A, Nakashima R, Murakami K, Yoshifuji H, Tanaka M, Tsuruyama T, Morinobu A, Hashimoto M. Enteric Toll-like receptor 7 stimulation causes acute exacerbation in lupus-susceptible mice. Clin Rheumatol. 2023 Apr;42(4):1185-1194. doi: 10.1007/s10067-022-06467-7. Epub 2022 Dec 14. PMID: 36515794.
7. Tabuchi Y, Katsushima M, Nishida Y, Shirakashi M, Tsuji H, Onizawa H, Kitagori K, Akizuki S, Nakashima R, Murakami K, Murata K, Yoshifuji H, Tanaka M, Morinobu A, Hashimoto M. Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation. Arthritis Res Ther. 2022 Jul 25;24(1):176. doi: 10.1186/s13075-022-02844-4. PMID: 35879738; PMCID: PMC9310491.
8. Matsuo H, Kamada M, Imamura A, Shimizu M, Inagaki M, Tsuji Y, Hashimoto M, Tanaka M, Ito H, Fujii Y. Machine learning-based prediction of relapse in rheumatoid arthritis patients using data on ultrasound examination and blood test. Sci Rep. 2022 May 4;12(1):7224. doi: 10.1038/s41598-022-11361-y. PMID: 35508670; PMCID: PMC9068780.
9. Masui S, Yonezawa A, Yokoyama K, Iwamoto N, Shimada T, Onishi A, Onizawa H, Fujii T, Murakami K, Murata K, Tanaka M, Nakagawa S, Hira D, Itohara K, Imai S, Nakagawa T, Hayakari M, Matsuda S, Morinobu A, Terada T, Matsubara K. N-terminus of Etanercept is Proteolytically Processed by Dipeptidyl Peptidase-4. Pharm Res. 2022 Oct;39(10):2541-2554. doi: 10.1007/s11095-022-03371-2. Epub 2022 Aug 19. PMID: 35986123.
10. Ma S, Murakami K, Tanaka K, Hashimoto M, Tanaka M, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Morinobu A, Mimori T. Fatostatin ameliorates inflammation without affecting cell viability. FEBS Open Bio. 2022 Mar;12(3):594-604. doi: 10.1002/2211-5463.13364. Epub 2022 Feb 1. PMID: 35015380; PMCID: PMC8886327.
11. Katsushima M, Minamino H, Shirakashi M, Onishi A, Fujita Y, Yamamoto W, Onizawa H, Tsuji H, Watanabe R, Murakami K, Fujii T, Murata K, Tanaka M, Inagaki N, Morinobu A, Hashimoto M. High plasma homocysteine level is associated with increased prevalence of the non-remission state in rheumatoid arthritis: Findings from the KURAMA cohort. Mod Rheumatol. 2023 Aug 25;33(5):911-917. doi: 10.1093/mr/roac106. PMID: 36069659.
12. Iwasaki T, Watanabe R, Ito H, Fujii T, Okuma K, Oku T, Hirayama Y, Ohmura K, Murata K, Murakami K, Yoshitomi H, Tanaka M, Matsuda S, Matsuda F, Morinobu A, Hashimoto M. Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis. Front Immunol. 2022 Jun 6;13:901437. doi: 10.3389/fimmu.2022.901437. PMID: 35734167; PMCID: PMC9208293.
13. Iwasaki T, Doi H, Tsuji H, Tabuchi Y, Hashimoto M, Kitagori K, Akizuki S, Murakami K, Nakashima R, Yoshifuji H, Yamamoto W, Tanaka M, Ohmura K, Morinobu A. Phenotypic landscape of systemic lupus erythematosus: An analysis of the Kyoto Lupus Cohort. Mod Rheumatol. 2022 Apr 18;32(3):571-576. doi: 10.1093/mr/roab020. PMID: 34894258.
14. Itaya T, Torii M, Hashimoto M, Jindai K, Yamamoto W, Tanigawa K, Urai Y, Kinoshita A, Nin K, Watanabe R, Murata K, Murakami K, Tanaka M, Ito H, Matsuda S, Morinobu A. Perceptions and behaviours related to COVID-19 in patients with rheumatoid arthritis: a cross-sectional study. Clin Rheumatol. 2022 Jan;41(1):45-51. doi: 10.1007/s10067-021-05840-2. Epub 2021 Sep 28. PMID: 34581890; PMCID: PMC8476713.
15. Doi K, Murata K, Ito S, Suzuki A, Terao C, Ishie S, Umemoto A, Murotani Y, Nishitani K, Yoshitomi H, Fujii T, Watanabe R, Hashimoto M, Murakami K, Tanaka M, Ito H, Park-Min KH, Ivashkiv LB, Morinobu A, Matsuda S. Role of Lysine-Specific Demethylase 1 in Metabolically Integrating Osteoclast Differentiation and Inflammatory Bone Resorption Through Hypoxia-Inducible Factor 1α and E2F1. Arthritis Rheumatol. 2022 Jun;74(6):948-960. doi: 10.1002/art.42074. Epub 2022 Apr 27. PMID: 35077015; PMCID: PMC9156537.
16. Ebina K, Hirano T, Maeda Y, Okita Y, Etani Y, Hirao M, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Kotani T, Shiba H, Katayama M, Yamamoto K, Kumanogoh A, Okada S, Nakata K. Add-on effectiveness of methotrexate or iguratimod in patients with rheumatoid arthritis exhibiting an inadequate response to Janus kinase inhibitors: The ANSWER cohort study. Mod Rheumatol. 2023 Jul 4;33(4):690-699. doi: 10.1093/mr/roac092. PMID: 35962543.
17. Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Takeuchi T, Yoshikawa A, Katayama M, Yamamoto K, Okita Y, Hirao M, Etani Y, Kumanogoh A, Okada S, Nakata K. Factors affecting drug retention of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study. Sci Rep. 2022 Jan 7;12(1):134. doi: 10.1038/s41598-021-04075-0. PMID: 34997059; PMCID: PMC8742057.
18. Jinno S, Akashi K, Onishi A, Nose Y, Yamashita M, Saegusa J. Comparative effectiveness of trimethoprim-sulfamethoxazole versus atovaquone for the prophylaxis of pneumocystis pneumonia in patients with connective tissue diseases receiving prolonged high-dose glucocorticoids. Rheumatol Int. 2022 Aug;42(8):1403-1409. doi: 10.1007/s00296-021-04945-w. Epub 2021 Jul 14. PMID: 34263352.
19. Kojima M, Kawahito Y, Sugihara T, Kojima T, Harada R, Hirata S, Hashimoto M, Hidaka T, Ishikawa H, Ito H, Kishimoto M, Kaneko Y, Matsui K, Matsui T, Matsushita I, Morinobu A, Nishida K, Tanaka E, Abe A, Ishitoku M, Asai S, Kida T, Onishi A, Takanashi S, Harigai M. Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design. BMC Rheumatol. 2022 Dec 26;6(1):90. doi: 10.1186/s41927-022-00322-7. PMID: 36567352; PMCID: PMC9791765.
20. Makino H, Kotani T, Hata K, Nishioka D, Yamamoto W, Yoshikawa A, Wada Y, Hiramatsu Y, Shiba H, Nagai K, Katayama M, Son Y, Amuro H, Onishi A, Akashi K, Hara R, Hirano T, Hashimoto M, Takeuchi T. Prognostic factors affecting respiratory-related death in patients with rheumatoid arthritis complicated by interstitial lung disease: An ANSWER cohort study. Mod Rheumatol. 2023 Aug 25;33(5):928-935. doi: 10.1093/mr/roac115. PMID: 36112486.
21. Murata K, Uozumi R, Hashimoto M, Ebina K, Akashi K, Onishi A, Nagai K, Yoshikawa A, Katayama M, Son Y, Amuro H, Hara R, Yamamoto W, Watanabe R, Murakami K, Tanaka M, Ito H, Morinobu A, Matsuda S. The real-world effectiveness of anti-RANKL antibody denosumab on the clinical fracture prevention in patients with rheumatoid arthritis: The ANSWER cohort study. Mod Rheumatol. 2022 Jul 1;32(4):834-838. doi: 10.1093/mr/roab043. PMID: 34910199.
22. Nakayama Y, Watanabe R, Murakami K, Murata K, Tanaka M, Ito H, Yamamoto W, Ebina K, Hata K, Hiramatsu Y, Katayama M, Son Y, Amuro H, Akashi K, Onishi A, Hara R, Yamamoto K, Ohmura K, Matsuda S, Morinobu A, Hashimoto M. Differential efficacy of TNF inhibitors with or without the immunoglobulin fragment crystallizable (Fc) portion in rheumatoid arthritis: the ANSWER cohort study. Rheumatol Int. 2022 Jul;42(7):1227-1234. doi: 10.1007/s00296-021-05086-w. Epub 2022 Mar 10. PMID: 35266034.
23. Omae K, Onishi A, Sahker E, Furukawa TA. US Food and Drug Administration Accelerated Approval Program for Nononcology Drug Indications Between 1992 and 2018. JAMA Netw Open. 2022 Sep 1;5(9):e2230973. doi: 10.1001/jamanetworkopen.2022.30973. PMID: 36083581; PMCID: PMC9463606.
24. Salanti G, Peter N, Tonia T, Holloway A, White IR, Darwish L, Low N, Egger M, Haas AD, Fazel S, Kessler RC, Herrman H, Kieling C, De Quervain DJF, Vigod SN, Patel V, Li T, Cuijpers P, Cipriani A, Furukawa TA, Leucht S; MHCOVID Crowd Investigators; Sambo AU, Onishi A, Sato A, Rodolico A, Oliveira Solis AC, Antoniou A, Kapfhammer A, Ceraso A, O’Mahony A, Lasserre AM, Ipekci AM, Concerto C, Zangani C, Igwesi-Chidobe C, Diehm C, Demir DD, Wang D, Ostinelli EG, Sahker E, Beraldi GH, Erzin G, Nelson H, Elkis H, Imai H, Wu H, Kamitsis I, Filis I, Michopoulos I, Bighelli I, Hong JSW, Ballesteros J, Smith KA, Yoshida K, Omae K, Trivella M, Tada M, Reinhard MA, Ostacher MJ, Müller M, Jaramillo NG, Ferentinos PP, Toyomoto R, Cortese S, Kishimoto S, Covarrubias-Castillo SA, Siafis S, Thompson T, Karageorgiou V, Chiocchia V, Zhu Y, Honda Y; MHCOVID Crowd Investigators†. The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population : A Systematic Review and Dose-Response Meta-analysis. Ann Intern Med. 2022 Nov;175(11):1560-1571. doi: 10.7326/M22-1507. Epub 2022 Oct 18. PMID: 36252247; PMCID: PMC9579966.
25. Tsutsumi Y, Tsujimoto Y, Tajika A, Omae K, Fujii T, Onishi A, Kataoka Y, Katsura M, Noma H, Sahker E, Ostinelli EG, Furukawa TA. Proportion attributable to contextual effects in general medicine: a meta-epidemiological study based on Cochrane reviews. BMJ Evid Based Med. 2023 Feb;28(1):40-47. doi: 10.1136/bmjebm-2021-111861. Epub 2022 Jul 19. PMID: 35853683; PMCID: PMC9887379.
26. Watanabe R, Oshima M, Nishioka N, Sada KE, Nagasaka K, Akiyama M, Ando T, Higuchi T, Inoue Y, Kida T, Mutoh T, Nakabayashi A, Onishi A, Sakai R, Waki D, Yamada Y, Yajima N, Tamura N, Kaname S, Harigai M. Systematic review and meta-analysis for 2023 clinical practice guidelines of the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis for the management of ANCA-associated vasculitis. Mod Rheumatol. 2023 Aug 25;33(5):982-989. doi: 10.1093/mr/roac114. PMID: 36112482.
27. Yoshida T, Tsuji H, Onishi A, Takase Y, Shirakashi M, Onizawa H, Hiwa R, Kitagori K, Akizuki S, Nakashima R, Tanaka M, Yoshifuji H, Morinobu A. Medium-term impact of the SARS-CoV-2 mRNA vaccine against disease activity in patients with systemic lupus erythematosus. Lupus Sci Med. 2022 Aug;9(1):e000727. doi: 10.1136/lupus-2022-000727. PMID: 35961691; PMCID: PMC9378947.
28. Ishie S, Ito H, Nakabo S, Tsuji H, Nakajima T, Tsuji Y, Inagaki M, Furu M, Hashimoto M, Murata K, Murakami K, Nishitani K, Tanaka M, Fujii Y, Matsuda S. Region specificity of rheumatoid foot symptoms associated with ultrasound-detected synovitis and joint destruction. Mod Rheumatol. 2022 Jan 5;32(1):127-135. doi: 10.1080/14397595.2021.1912905. PMID: 33851898.
29. Tomizawa T, Ito H, Murata K, Matsuda S. A unique salvage operation strategy: implantation of the ulnar total elbow component to the radius to overcome large ulnar bone defect caused by infection after total elbow arthroplasty. Mod Rheumatol Case Rep. 2022 Jan 7;6(1):115-119. doi: 10.1093/mrcr/rxab015. PMID: 34499143.
30. Ito H, Murata K, Sobue Y, Kojima T, Nishida K, Matsushita I, Kawahito Y, Kojima M, Hirata S, Kaneko Y, Kishimoto M, Kohno M, Mori M, Morinobu A, Murashima A, Seto Y, Sugihara T, Tanaka E, Nakayama T, Harigai M. Comprehensive risk analysis of postoperative complications in patients with rheumatoid arthritis for the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. Mod Rheumatol. 2022 Feb 28;32(2):296-306. doi: 10.1080/14397595.2021.1913824. PMID: 33855932.
31. Watanabe R, Hashimoto M, Murata K, Murakami K, Tanaka M, Ohmura K, Ito H, Matsuda S. Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort. Immunol Med. 2022 Mar;45(1):35-44. doi: 10.1080/25785826.2021.1928383. Epub 2021 May 25. PMID: 34033729.
32. Shirakashi M, Maruya M, Hirota K, Tsuruyama T, Matsuo T, Watanabe R, Murata K, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Elewaut D, Sakaguchi S, Fagarasan S, Mimori T, Hashimoto M. Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity. Arthritis Rheumatol. 2022 Apr;74(4):641-653. doi: 10.1002/art.42016. Epub 2022 Feb 25. PMID: 34725966.
33. Yoshida S, Nishitani K, Yoshitomi H, Kuriyama S, Nakamura S, Fujii T, Saito M, Kobori Y, Murakami A, Murata K, Ito H, Ueno H, Matsuda S. Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2. Arthritis Rheumatol. 2023 Jun;75(6):950-960. doi: 10.1002/art.42424. Epub 2023 Mar 9. PMID: 36530127.
34. Fujii T, Wada S, Carballo CB, Bell RD, Morita W, Nakagawa Y, Liu Y, Chen D, Pannellini T, Sokhi UK, Deng XH, Park-Min KH, Rodeo SA, Ivashkiv LB. Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone-to-Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice. JBMR Plus. 2022 May 31;6(7):e10635. doi: 10.1002/jbm4.10635. PMID: 35866148; PMCID: PMC9289991.
35. Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S. B cell-derived GABA elicits IL-10⁺ macrophages to limit anti-tumour immunity. Nature. 2021 Nov;599(7885):471-476. doi: 10.1038/s41586-021-04082-1. Epub 2021 Nov 3. PMID: 34732892; PMCID: PMC8599023.
36. Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC; BioBank Japan Project; Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S. Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis. Nat Genet. 2022 Nov;54(11):1640-1651. doi: 10.1038/s41588-022-01213-w. Epub 2022 Nov 4. PMID: 36333501; PMCID: PMC10165422.
37. Nakajima T, Watanabe R, Hashimoto M, Murata K, Murakami K, Tanaka M, Ito H, Yamamoto W, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Matsuda S, Morinobu A. Neutrophil count reduction 1 month after initiating tocilizumab can predict clinical remission within 1 year in rheumatoid arthritis patients. Rheumatol Int. 2022 Nov;42(11):1983-1991. doi: 10.1007/s00296-021-04944-x. Epub 2021 Jul 9. PMID: 34241658.
38. Torii M, Itaya T, Minamino H, Katsushima M, Fujita Y, Tanaka H, Oshima Y, Watanabe R, Ito H, Arai H, Hashimoto M. Management of sarcopenia in patients with rheumatoid arthritis. Mod Rheumatol. 2023 Apr 13;33(3):435-440. doi: 10.1093/mr/roac095. PMID: 35986513.
39. Yaku A, Ishikawa Y, Iwasaki T, Hiwa R, Matsuo K, Saji H, Yurugi K, Miura Y, Furu M, Ito H, Fujii T, Maekawa T, Hashimoto M, Ohmura K, Mimori T, Terao C. Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF. Rheumatology (Oxford). 2023 May 2;62(5):2015-2020. doi: 10.1093/rheumatology/keac593. PMID: 36250908.

2021年

1. Iwasaki T, Doi H, Tsuji H, Tabuchi Y, Hashimoto M, Kitagori K, Akizuki S, Murakami K, Nakashima R, Yoshifuji H, Yamamoto W, Tanaka M, Ohmura K, Morinobu A. Phenotypic landscape of systemic lupus erythematosus: An analysis of the Kyoto Lupus Cohort. Mod Rheumatol. 2022 Apr 18;32(3):571-576. doi: 10.1093/mr/roab020. PMID: 34894258.
2. Kadoba K, Watanabe R, Iwasaki T, Nakajima T, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Ohmura K, Morinobu A, Terao C, Yoshifuji H. A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis. Sci Rep. 2021 Jul 1;11(1):13667. doi: 10.1038/s41598-021-93213-9. PMID: 34211061; PMCID: PMC8249518.
3. Kuramoto N, Saito S, Fujii T, Kaneko Y, Saito R, Tanaka M, Takada H, Nakano K, Saito K, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Characteristics of rheumatoid arthritis with immunodeficiency-associated lymphoproliferative disorders to regress spontaneously by the withdrawal of methotrexate and their clinical course: A retrospective, multicenter, case-control study. Mod Rheumatol. 2022 Jan 5;32(1):24-31. doi: 10.1080/14397595.2021.1879362. PMID: 33496194.
4. Saito R, Tanaka M, Ito H, Kuramoto N, Fujii T, Saito S, Kaneko Y, Nakano K, Saito K, Takada H, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Overall survival and post-spontaneous regression relapse-free survival of patients with lymphoproliferative disorders associated with rheumatoid arthritis: a multi-center retrospective cohort study. Mod Rheumatol. 2022 Jan 5;32(1):50-58. doi: 10.1080/14397595.2020.1866837. PMID: 33336615.
5. Takada H, Kaneko Y, Nakano K, Tanaka M, Fujii T, Saito K, Sugimoto N, Sasaki S, Saito S, Saito R, Kuramoto N, Harigai M, Suzuki Y. Clinicopathological characteristics of lymphoproliferative disorders in 232 patients with rheumatoid arthritis in Japan: A retrospective, multicenter, descriptive study. Mod Rheumatol. 2022 Jan 5;32(1):32-40. doi: 10.1080/14397595.2021.1899570. PMID: 33705243.
6. Takase Y, Iwasaki T, Doi H, Tsuji H, Hashimoto M, Ueno K, Inaba R, Kozuki T, Taniguchi M, Tabuchi Y, Watanabe R, Kitagori K, Akizuki S, Murakami K, Nakashima R, Yoshifuji H, Itaya T, Yamamoto W, Uozumi R, Tanaka M, Ohmura K, Morinobu A. Correlation between irreversible organ damage and the quality of life of patients with systemic lupus erythematosus: The Kyoto Lupus Cohort survey. Lupus. 2021 Sep;30(10):1577-1585. doi: 10.1177/09612033211025614. Epub 2021 Jun 14. PMID: 34121502.
7. Tanaka M. Conflict between efficacy and economy in rheumatoid arthritis treatment: Iguratimod is found at a compromise. Lancet Reg Health West Pac. 2021 Apr 12;10:100144. doi: 10.1016/j.lanwpc.2021.100144. PMID: 34327351; PMCID: PMC8315648.
8. Doi K, Murata K, Ito S, Suzuki A, Terao C, Ishie S, Umemoto A, Murotani Y, Nishitani K, Yoshitomi H, Fujii T, Watanabe R, Hashimoto M, Murakami K, Tanaka M, Ito H, Park-Min KH, Ivashkiv LB, Morinobu A, Matsuda S. Role of Lysine-Specific Demethylase 1 in Metabolically Integrating Osteoclast Differentiation and Inflammatory Bone Resorption Through Hypoxia-Inducible Factor 1α and E2F1. Arthritis Rheumatol. 2022 Jun;74(6):948-960. doi: 10.1002/art.42074. Epub 2022 Apr 27. PMID: 35077015; PMCID: PMC9156537.
9. Ma S, Murakami K, Tanaka K, Hashimoto M, Tanaka M, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Morinobu A, Mimori T. Fatostatin ameliorates inflammation without affecting cell viability. FEBS Open Bio. 2022 Mar;12(3):594-604. doi: 10.1002/2211-5463.13364. Epub 2022 Feb 1. PMID: 35015380; PMCID: PMC8886327.
10. Tsuji H, Kuramoto N, Sasai T, Shirakashi M, Onizawa H, Kitagori K, Akizuki S, Nakashima R, Watanabe R, Onishi A, Murakami K, Yoshifuji H, Tanaka M, Hashimoto M, Ohmura K, Morinobu A. Autoantibody profiles associated with morbidity and mortality in scleroderma renal crisis. Rheumatology (Oxford). 2022 Oct 6;61(10):4130-4135. doi: 10.1093/rheumatology/keac047. PMID: 35078211.
11. Yamaguchi E, Kadoba K, Watanabe R, Iwasaki T, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Morinobu A, Yoshifuji H. Clinical profile and outcome of large-vessel giant cell arteritis in Japanese patients: A single-centre retrospective cohort study. Mod Rheumatol. 2023 Jan 3;33(1):175-181. doi: 10.1093/mr/roac013. PMID: 35141755.
12. Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Takeuchi T, Yoshikawa A, Katayama M, Yamamoto K, Okita Y, Hirao M, Etani Y, Kumanogoh A, Okada S, Nakata K. Factors affecting drug retention of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study. Sci Rep. 2022 Jan 7;12(1):134. doi: 10.1038/s41598-021-04075-0. PMID: 34997059; PMCID: PMC8742057.
13. Nakayama Y, Hashimoto M, Watanabe R, Murakami K, Murata K, Tanaka M, Ito H, Yamamoto W, Ebina K, Hata K, Hiramatsu Y, Katayama M, Son Y, Amuro H, Akashi K, Onishi A, Hara R, Yamamoto K, Ohmura K, Matsuda S, Morinobu A. Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study. Scand J Rheumatol. 2022 Nov;51(6):431-440. doi: 10.1080/03009742.2021.1947005. Epub 2021 Sep 13. PMID: 34511031.
14. Hattori M, Novick D, Takaura K, Tanizawa Y, Kawaguchi T, Haro JM, Monistrol-Mula A, Onishi A, Iwata H. A systematic literature review of prognostic factors in patients with HR+/HER2- advanced breast cancer in Japan. Jpn J Clin Oncol. 2021 Oct 5;51(10):1498-1508. doi: 10.1093/jjco/hyab131. PMID: 34417808; PMCID: PMC8491537.
15. Jinno S, Akashi K, Onishi A, Nose Y, Yamashita M, Saegusa J. Comparative effectiveness of trimethoprim-sulfamethoxazole versus atovaquone for the prophylaxis of pneumocystis pneumonia in patients with connective tissue diseases receiving prolonged high-dose glucocorticoids. Rheumatol Int. 2022 Aug;42(8):1403-1409. doi: 10.1007/s00296-021-04945-w. Epub 2021 Jul 14. PMID: 34263352.
16. Onishi A, Akashi K, Yamamoto W, Ebina K, Murata K, Hara R, Katayama M, Nagai K, Hirano T, Amuro H, Son Y, Yamamoto K, Hashimoto M, Morinobu A. The Association of Disease Activity and Estimated GFR in Patients With Rheumatoid Arthritis: Findings From the ANSWER Study. Am J Kidney Dis. 2021 Nov;78(5):761-764. doi: 10.1053/j.ajkd.2021.02.338. Epub 2021 May 10. PMID: 33984404.
17. Maeda Y, Hirano T, Ebina K, Hara R, Hashimoto M, Yamamoto W, Murakami K, Kotani T, Hata K, Son Y, Amuro H, Onishi A, Jinno S, Katayama M, Kumanogoh A. Comparison of efficacy between anti-IL-6 receptor antibody and other biological disease-modifying antirheumatic drugs in the patients with rheumatoid arthritis who have knee joint involvement: the ANSWER cohort, retrospective study. Rheumatol Int. 2021 Jul;41(7):1233-1241. doi: 10.1007/s00296-021-04862-y. Epub 2021 Apr 26. PMID: 33903963.
18. Jinno S, Onishi A, Dubreuil M, Hashimoto M, Yamamoto W, Murata K, Takeuchi T, Kotani T, Maeda Y, Ebina K, Son Y, Amuro H, Hara R, Katayama M, Saegusa J. Comparison of the drug retention and reasons for discontinuation of tumor necrosis factor inhibitors and interleukin-6 inhibitors in Japanese patients with elderly-onset rheumatoid arthritis-the ANSWER cohort study. Arthritis Res Ther. 2021 Apr 15;23(1):116. doi: 10.1186/s13075-021-02496-w. PMID: 33858490; PMCID: PMC8048332.
19. Kimachi M, Onishi A, Tajika A, Kimachi K, Furukawa TA. Systematic differences in effect estimates between observational studies and randomized control trials in meta-analyses in nephrology. Sci Rep. 2021 Mar 17;11(1):6088. doi: 10.1038/s41598-021-85519-5. PMID: 33731727; PMCID: PMC7971062.
20. Ebina K, Hirano T, Maeda Y, Yamamoto W, Hashimoto M, Murata K, Onishi A, Jinno S, Hara R, Son Y, Amuro H, Takeuchi T, Yoshikawa A, Katayama M, Yamamoto K, Hirao M, Okita Y, Kumanogoh A, Nakata K. Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study. Clin Rheumatol. 2021 Jul;40(7):2673-2680. doi: 10.1007/s10067-021-05609-7. Epub 2021 Jan 29. PMID: 33515115.
21. Michopoulos I, Furukawa TA, Noma H, Kishimoto S, Onishi A, Ostinelli EG, Ciharova M, Miguel C, Karyotaki E, Cuijpers P. Different control conditions can produce different effect estimates in psychotherapy trials for depression. J Clin Epidemiol. 2021 Apr;132:59-70. doi: 10.1016/j.jclinepi.2020.12.012. Epub 2020 Dec 15. PMID: 33338564.
22. Tomizawa T, Nishitani K, Ito H, Okae Y, Morita Y, Doi K, Saito M, Ishie S, Yoshida S, Murata K, Yoshitomi H, Kuroda Y, Matsuda S. The limitations of mono- and combination antibiotic therapies on immature biofilms in a murine model of implant-associated osteomyelitis. J Orthop Res. 2021 Feb;39(2):449-457. doi: 10.1002/jor.24956. Epub 2020 Dec 23. PMID: 33325059.
23. Ono K, Shimizu T, Fujibayashi S, Otsuki B, Murata K, Sakamoto A, Matsuda S. Predictive Value of Heterogeneously Enhanced Magnetic Resonance Imaging Findings With Computed Tomography Evidence of Calcification for Severe Motor Deficits in Spinal Meningioma. Neurospine. 2021 Mar;18(1):163-169. doi: 10.14245/ns.2040494.247. Epub 2020 Dec 4. PMID: 33285060; PMCID: PMC8021834.
24. Minamino H, Katsushima M, Torii M, Hashimoto M, Fujita Y, Ikeda K, Yamamoto W, Watanabe R, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Ohmura K, Arai H, Inagaki N, Matsuda S. Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis. Sci Rep. 2021 Mar 3;11(1):5104. doi: 10.1038/s41598-021-84479-0. PMID: 33658620; PMCID: PMC7930016.
25. Minamino H, Katsushima M, Hashimoto M, Fujita Y, Yoshida T, Ikeda K, Isomura N, Oguri Y, Yamamoto W, Watanabe R, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Ohmura K, Matsuda S, Inagaki N, Morinobu A. Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther. 2021 Mar 27;23(1):96. doi: 10.1186/s13075-021-02479-x. PMID: 33773587; PMCID: PMC8004419.
26. Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S. A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis. Sci Rep. 2020 Nov 27;10(1):20787. doi: 10.1038/s41598-020-77735-2. Erratum in: Sci Rep. 2021 Mar 29;11(1):7442. doi: 10.1038/s41598-021-86883-y. PMID: 33247195; PMCID: PMC7695735.
27. Ono K, Otsuki B, Fujibayashi S, Shimizu T, Murata K, Matsuda S. Subtotal En Bloc Resection of the Fourth Lumbar Vertebra for Giant Cell Tumor Using Combined Posterior and Lateral Retroperitoneal Approach. Spine Surg Relat Res. 2021 Jan 12;5(6):442-445. doi: 10.22603/ssrr.2020-0212. PMID: 34966873; PMCID: PMC8668219.
28. Fujibayashi S, Murata K, Shimizu T, Otsuki B, Masamoto K, Shimizu Y, Matsuda S. An Observational Survey of Nail and Skin of Spine Surgeons-Possible Damage by Occupational Ionizing Radiation Exposure. Spine Surg Relat Res. 2021 Feb 9;5(6):359-364. doi: 10.22603/ssrr.2020-0204. PMID: 34966861; PMCID: PMC8668220.
29. Minamino H, Katsushima M, Hashimoto M, Fujita Y, Torii M, Ikeda K, Isomura N, Oguri Y, Yamamoto W, Watanabe R, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Uda M, Nin K, Arai H, Matsuda S, Morinobu A, Inagaki N. Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database. PLoS One. 2021 Aug 5;16(8):e0255526. doi: 10.1371/journal.pone.0255526. PMID: 34351967; PMCID: PMC8341538.
30. Wada K, Sakamoto A, Kato R, Noguchi T, Shimizu T, Otsuki B, Murata K, Fujibayashi S, Matsuda S. Chondrosarcoma Arising from the Posterior Iliac Crest Extending into the Spinal Canal. Case Rep Orthop. 2021 Jul 17;2021:5510075. doi: 10.1155/2021/5510075. PMID: 34336329; PMCID: PMC8313319.
31. Ma S, Murakami K, Saito R, Ito H, Murata K, Nishitani K, Hashimoto M, Tanaka M, Taniguchi M, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Morinobu A, Mimori T. Increased Ratio of CD14⁺⁺CD80⁺ Cells/CD14⁺⁺CD163⁺ Cells in the Infrapatellar Fat Pad of End-Stage Arthropathy Patients. Front Immunol. 2021 Nov 26;12:774177. doi: 10.3389/fimmu.2021.774177. PMID: 34899727; PMCID: PMC8662627.
32. Nakae K, Masui S, Yonezawa A, Hashimoto M, Watanabe R, Murata K, Murakami K, Tanaka M, Ito H, Yokoyama K, Iwamoto N, Shimada T, Nakamura M, Denda M, Itohara K, Nakagawa S, Ikemi Y, Imai S, Nakagawa T, Hayakari M, Matsubara K. Potential application of measuring serum infliximab levels in rheumatoid arthritis management: A retrospective study based on KURAMA cohort data. PLoS One. 2021 Oct 13;16(10):e0258601. doi: 10.1371/journal.pone.0258601. PMID: 34644354; PMCID: PMC8513849.
33. Itaya T, Torii M, Hashimoto M, Tanigawa K, Urai Y, Kinoshita A, Nin K, Jindai K, Watanabe R, Murata K, Murakami K, Tanaka M, Ito H, Matsuda S, Morinobu A. Prevalence of anxiety and depression in patients with rheumatoid arthritis before and during the COVID-19 pandemic. Rheumatology (Oxford). 2021 Apr 6;60(4):2023-2024. doi: 10.1093/rheumatology/keab065. PMID: 33502497; PMCID: PMC7928586.
34. Watanabe R, Hashimoto M, Murata K, Murakami K, Tanaka M, Ohmura K, Ito H, Matsuda S. Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort. Immunol Med. 2022 Mar;45(1):35-44. doi: 10.1080/25785826.2021.1928383. Epub 2021 May 25. PMID: 34033729.
35. Otsuki B, Fujibayashi S, Tanida S, Shimizu T, Murata K, Matsuda S. Possible Association of Pedicle Screw Diameter on Pseudoarthrosis Rate After Transforaminal Lumbar Interbody Fusion. World Neurosurg. 2021 Jun;150:e155-e161. doi: 10.1016/j.wneu.2021.02.117. Epub 2021 Mar 5. PMID: 33684576.
36. Shimizu T, Fujibayashi S, Otsuki B, Murata K, Matsuda S. Indirect decompression via oblique lateral interbody fusion for severe degenerative lumbar spinal stenosis: a comparative study with direct decompression transforaminal/posterior lumbar interbody fusion. Spine J. 2021 Jun;21(6):963-971. doi: 10.1016/j.spinee.2021.01.025. Epub 2021 Feb 2. PMID: 33540124.
37. Otsuki B, Okamoto T, Fujibayashi S, Sakamoto A, Toguchida J, Murata K, Shimizu T, Matsuda S. Rigid reconstruction with periacetabular multiple screws after the resection of malignant pelvic tumours involving the sacroiliac joint. Int Orthop. 2021 Jul;45(7):1793-1802. doi: 10.1007/s00264-021-05096-0. Epub 2021 Jun 4. PMID: 34086124.
38. Nakajima T, Watanabe R, Hashimoto M, Murata K, Murakami K, Tanaka M, Ito H, Yamamoto W, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Matsuda S, Morinobu A. Neutrophil count reduction 1 month after initiating tocilizumab can predict clinical remission within 1 year in rheumatoid arthritis patients. Rheumatol Int. 2022 Nov;42(11):1983-1991. doi: 10.1007/s00296-021-04944-x. Epub 2021 Jul 9. PMID: 34241658.
39. Masuda S, Fujibayashi S, Kimura H, Tanida S, Otsuki B, Murata K, Shimizu T, Matsuda S. Salvage Oblique Lateral Interbody Fusion for Pseudarthrosis after Posterior/Transforaminal Lumbar Interbody Fusion: A Technical Note. World Neurosurg. 2021 Aug;152:107-112. doi: 10.1016/j.wneu.2021.06.020. Epub 2021 Jun 12. PMID: 34129982.
40. Murata K, Uozumi R, Hashimoto M, Ebina K, Akashi K, Onishi A, Nagai K, Yoshikawa A, Katayama M, Son Y, Amuro H, Hara R, Yamamoto W, Watanabe R, Murakami K, Tanaka M, Ito H, Morinobu A, Matsuda S. The real-world effectiveness of anti-RANKL antibody denosumab on the clinical fracture prevention in patients with rheumatoid arthritis: The ANSWER cohort study. Mod Rheumatol. 2022 Jul 1;32(4):834-838. doi: 10.1093/mr/roab043. PMID: 34910199.
41. Ishie S, Ito H, Nakabo S, Tsuji H, Nakajima T, Tsuji Y, Inagaki M, Furu M, Hashimoto M, Murata K, Murakami K, Nishitani K, Tanaka M, Fujii Y, Matsuda S. Region specificity of rheumatoid foot symptoms associated with ultrasound-detected synovitis and joint destruction. Mod Rheumatol. 2022 Jan 5;32(1):127-135. doi: 10.1080/14397595.2021.1912905. PMID: 33851898.
42. Tomizawa T, Ito H, Murata K, Matsuda S. A unique salvage operation strategy: implantation of the ulnar total elbow component to the radius to overcome large ulnar bone defect caused by infection after total elbow arthroplasty. Mod Rheumatol Case Rep. 2022 Jan 7;6(1):115-119. doi: 10.1093/mrcr/rxab015. PMID: 34499143.
43. Ikeda N, Fujibayashi S, Otsuki B, Masamoto K, Shimizu T, Shimizu Y, Murata K, Matsuda S. The degenerative changes of the sacroiliac joint after S2 alar-iliac screw placement. J Neurosurg Spine. 2021 Oct 1;36(2):287-293. doi: 10.3171/2021.4.SPINE202035. PMID: 34598160.
44. Minamino H, Katsushima M, Torii M, Yamamoto W, Fujita Y, Ikeda K, Okamura E, Murakami K, Watanabe R, Murata K, Ito H, Tanaka M, Arai H, Matsuda S, Morinobu A, Inagaki N, Hashimoto M. Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis. Sci Rep. 2021 Oct 14;11(1):20485. doi: 10.1038/s41598-021-99894-6. PMID: 34650186; PMCID: PMC8516961.
45. Shirakashi M, Maruya M, Hirota K, Tsuruyama T, Matsuo T, Watanabe R, Murata K, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Elewaut D, Sakaguchi S, Fagarasan S, Mimori T, Hashimoto M. Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity. Arthritis Rheumatol. 2022 Apr;74(4):641-653. doi: 10.1002/art.42016. Epub 2022 Feb 25. PMID: 34725966.
46. Onishi A, Akashi K, Yamamoto W, Ebina K, Murata K, Hara R, Katayama M, Nagai K, Hirano T, Amuro H, Son Y, Yamamoto K, Hashimoto M, Morinobu A. The Association of Disease Activity and Estimated GFR in Patients With Rheumatoid Arthritis: Findings From the ANSWER Study. Am J Kidney Dis. 2021 Nov;78(5):761-764. doi: 10.1053/j.ajkd.2021.02.338. Epub 2021 May 10. PMID: 33984404.
47. Yoshida T, Hashimoto M, Horiguchi G, Murakami K, Murata K, Nishitani K, Watanabe R, Yamamoto W, Tanaka M, Morinobu A, Ito H, Matsuda S, Uehara R. Pain catastrophizing hinders Disease Activity Score 28 – erythrocyte sedimentation rate remission of rheumatoid arthritis in patients with normal C-reactive protein levels. Int J Rheum Dis. 2021 Dec;24(12):1520-1529. doi: 10.1111/1756-185X.14231. Epub 2021 Oct 26. PMID: 34698449.
48. Itaya T, Torii M, Hashimoto M, Jindai K, Yamamoto W, Tanigawa K, Urai Y, Kinoshita A, Nin K, Watanabe R, Murata K, Murakami K, Tanaka M, Ito H, Matsuda S, Morinobu A. Perceptions and behaviours related to COVID-19 in patients with rheumatoid arthritis: a cross-sectional study. Clin Rheumatol. 2022 Jan;41(1):45-51. doi: 10.1007/s10067-021-05840-2. Epub 2021 Sep 28. PMID: 34581890; PMCID: PMC8476713.
49. Fujii T, Murata K, Mun SH, Bae S, Lee YJ, Pannellini T, Kang K, Oliver D, Park-Min KH, Ivashkiv LB. MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS. Bone Res. 2021 Jan 11;9(1):4. doi: 10.1038/s41413-020-00120-2. PMID: 33424022; PMCID: PMC7797478.
50. Bae S, Park PSU, Lee Y, Mun SH, Giannopoulou E, Fujii T, Lee KP, Violante SN, Cross JR, Park-Min KH. MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Rep. 2021 Jun 15;35(11):109264. doi: 10.1016/j.celrep.2021.109264. PMID: 34133930; PMCID: PMC8257047.
51. Onizawa H, Kato H, Kimura H, Kudo T, Soda N, Shimizu S, Funabiki M, Yagi Y, Nakamoto Y, Priller J, Nishikomori R, Heike T, Yan N, Tsujimura T, Mimori T, Fujita T. Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5. Int Immunol. 2021 Mar 31;33(4):225-240. doi: 10.1093/intimm/dxaa073. PMID: 33165593.
52. Mukoyama H, Shirakashi M, Tanaka N, Iwasaki T, Nakajima T, Onizawa H, Tsuji H, Kitagori K, Akizuki S, Nakashima R, Murakami K, Tanaka M, Morinobu A, Yoshifuji H. The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection. Arthritis Res Ther. 2021 Dec 3;23(1):293. doi: 10.1186/s13075-021-02675-9. PMID: 34857042; PMCID: PMC8641170.
53. Matsuo T, Sasai T, Nakashima R, Kuwabara Y, Kato ET, Murakami I, Onizawa H, Akizuki S, Murakami K, Hashimoto M, Yoshifuji H, Tanaka M, Morinobu A, Mimori T. ECG Changes Through Immunosuppressive Therapy Indicate Cardiac Abnormality in Anti-MDA5 Antibody-Positive Clinically Amyopathic Dermatomyositis. Front Immunol. 2022 Jan 7;12:765140. doi: 10.3389/fimmu.2021.765140. PMID: 35069538; PMCID: PMC8776991.

2020年

1. Matsuo H, Imamura A, Shimizu M, Inagaki M, Tsuji Y, Nakabo S, Hashimoto M, Ito H, Tanaka S, Mimori T, Fujii Y. Prediction of recurrence and remission using superb microvascular imaging in rheumatoid arthritis. J Med Ultrason (2001). 2020 Jan;47(1):131-138. doi: 10.1007/s10396-019-00978-8. Epub 2019 Sep 25. PMID: 31555946.
2. Minamino H, Katsushima M, Yoshida T, Hashimoto M, Fujita Y, Shirakashi M, Yamamoto W, Murakami K, Murata K, Nishitani K, Tanaka M, Ito H, Inagaki N, Matsuda S. Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. PLoS One. 2020 Mar 3;15(3):e0229998. doi: 10.1371/journal.pone.0229998. PMID: 32126127; PMCID: PMC7053773.
3. Murata K, Ito H, Hashimoto M, Murakami K, Watanabe R, Tanaka M, Yamamoto W, Matsuda S. Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort. Arthritis Res Ther. 2020 Nov 12;22(1):268. doi: 10.1186/s13075-020-02366-x. PMID: 33183344; PMCID: PMC7664066.
4. Watanabe R, Berry GJ, Liang DH, Goronzy JJ, Weyand CM. Cellular Signaling Pathways in Medium and Large Vessel Vasculitis. Front Immunol. 2020 Sep 25;11:587089. doi: 10.3389/fimmu.2020.587089. PMID: 33072134; PMCID: PMC7544845.
5. Nakaoka Y, Isobe M, Tanaka Y, Ishii T, Ooka S, Niiro H, Tamura N, Banno S, Yoshifuji H, Sakata Y, Kawakami A, Atsumi T, Furuta S, Kohsaka H, Suzuki K, Hara R, Maejima Y, Tsukamoto H, Takasaki Y, Yamashita K, Okada N, Yamakido S, Takei S, Yokota S, Nishimoto N. Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study. Rheumatology (Oxford). 2020 Sep 1;59(9):2427-2434. doi: 10.1093/rheumatology/kez630. PMID: 31951279; PMCID: PMC7449811.
6. Yoshida M, Hariya T, Yokokura S, Kobayashi W, Watanabe R, Ishii T, Nakazawa T. Concomitant herpes simplex keratitis and autoimmune-associated ulcerative keratitis in rheumatoid arthritis patients. Am J Ophthalmol Case Rep. 2020 Mar 9;18:100648. doi: 10.1016/j.ajoc.2020.100648. PMID: 32274443; PMCID: PMC7136173.
7. Watanabe R, Hashimoto M, Morinobu A. Correspondence on ‘The use of tocilizumab and tofacitinib in patients with resolved hepatitis B infection: a case series’. Ann Rheum Dis. 2023 Sep;82(9):e212. doi: 10.1136/annrheumdis-2020-219270. Epub 2020 Nov 3. PMID: 33144301.
8. Watanabe R. JAK inhibitors as promising agents for refractory Takayasu arteritis. Ann Rheum Dis. 2022 Apr;81(4):e67. doi: 10.1136/annrheumdis-2020-217577. Epub 2020 Apr 27. PMID: 32340977.
9. Kondo H, Watanabe R, Okazaki S, Kuriyama K, Ochi T, Yamada G, Sugiura A, Chiba H, Tsukada A, Taniuchi S, Igarashi T, Kudo M, Harigae H, Fujii H. JAK2 mutation-positive polycythaemia vera associated with IgA vasculitis and nephrotic syndrome: a case report. Mod Rheumatol Case Rep. 2020 Jul;4(2):289-295. doi: 10.1080/24725625.2020.1728061. Epub 2020 Feb 13. PMID: 33087019.
10. Watanabe R, Igarashi T, Takahashi T, Kondo H, Okazaki S, Kudo M, Ohyanagi M, Gamoh M. Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis. Tohoku J Exp Med. 2020 Oct;252(2):133-141. doi: 10.1620/tjem.252.133. PMID: 33028756.
11. Watanabe R, Berry GJ, Liang DH, Goronzy JJ, Weyand CM. Pathogenesis of Giant Cell Arteritis and Takayasu Arteritis-Similarities and Differences. Curr Rheumatol Rep. 2020 Aug 26;22(10):68. doi: 10.1007/s11926-020-00948-x. PMID: 32845392; PMCID: PMC9112376.
12. Sumiyoshi R, Hidaka T, Koga T, Okada A, Fukuda T, Ishii T, Ueki Y, Kodera T, Nakashima M, Takahashi Y, Honda S, Horai Y, Watanabe R, Okuno H, Aramaki T, Izumiyama T, Takai O, Miyashita T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Eguchi K, Kawakami A; and the Japanese RA Patients with RRP Study Group. Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan. Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1096-1101. Epub 2020 Sep 1. PMID: 32896260.
13. Murakami I, Murakami K, Hashimoto M, Tanaka M, Ito H, Fujii T, Torii M, Ikeda K, Kuwabara A, Tanaka K, Yoshida A, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Usui T, Morita S, Mimori T. Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis. PLoS One. 2020 Feb 13;15(2):e0228852. doi: 10.1371/journal.pone.0228852. PMID: 32053642; PMCID: PMC7018088.
14. Tanaka Y, Oba K, Koike T, Miyasaka N, Mimori T, Takeuchi T, Hirata S, Tanaka E, Yasuoka H, Kaneko Y, Murakami K, Koga T, Nakano K, Amano K, Ushio K, Atsumi T, Inoo M, Hatta K, Mizuki S, Nagaoka S, Tsunoda S, Dobashi H, Horie N, Sato N. Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial. Ann Rheum Dis. 2020 Jan;79(1):94-102. doi: 10.1136/annrheumdis-2019-216169. Epub 2019 Oct 19. PMID: 31630117; PMCID: PMC6937411.
15. Murata K, Hashimoto M, Yamamoto W, Son Y, Amuro H, Nagai K, Takeuchi T, Katayama M, Maeda Y, Ebina K, Hara R, Jinno S, Onishi A, Murakami K, Tanaka M, Ito H, Mimori T, Matsuda S. The family history of rheumatoid arthritis in anti-cyclic citrullinated peptide antibody-positive patient is not a predictor of poor clinical presentation and treatment response with modern classification criteria and treatment strategy: the ANSWER cohort study. Rheumatol Int. 2020 Feb;40(2):217-225. doi: 10.1007/s00296-019-04464-9. Epub 2019 Oct 16. PMID: 31620864.
16. Kaneko Y, Kameda H, Ikeda K, Ishii T, Murakami K, Takamatsu H, Tanaka Y, Abe T, Takeuchi T. Response to: ‘Some concerns from Turkey’ by Bilgin et al. Ann Rheum Dis. 2020 Feb;79(2):e16. doi: 10.1136/annrheumdis-2018-214776. Epub 2018 Dec 8. PMID: 30530826.
17. Tsuji H, Nakashima R, Hosono Y, Imura Y, Yagita M, Yoshifuji H, Hirata S, Nojima T, Sugiyama E, Hatta K, Taguchi Y, Katayama M, Tanizawa K, Handa T, Uozumi R, Akizuki S, Murakami K, Hashimoto M, Tanaka M, Ohmura K, Mimori T. Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis. Arthritis Rheumatol. 2020 Mar;72(3):488-498. doi: 10.1002/art.41105. Epub 2020 Jan 27. PMID: 31524333.
18. Nakabo S, Ohmura K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Mimori T. Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis. Mod Rheumatol. 2020 Mar;30(2):345-349. doi: 10.1080/14397595.2019.1583819. Epub 2019 May 2. PMID: 30789095.
19. Ito H, Tsuji S, Nakayama M, Mochida Y, Nishida K, Ishikawa H, Kojima T, Matsumoto T, Kubota A, Mochizuki T, Sakuraba K, Matsushita I, Nakajima A, Hara R, Haraguchi A, Matsubara T, Kanbe K, Nakagawa N, Hamaguchi M, Momohara S; JOSRA Consortium. Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs? J Rheumatol. 2020 Apr;47(4):502-509. doi: 10.3899/jrheum.181100. Epub 2019 Jun 15. PMID: 31203226.
20. Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K. Biofilm Producing Staphylococcus epidermidis (RP62A Strain) Inhibits Osseous Integration Without Osteolysis and Histopathology in a Murine Septic Implant Model. J Orthop Res. 2020 Apr;38(4):852-860. doi: 10.1002/jor.24512. Epub 2019 Nov 19. PMID: 31692081; PMCID: PMC7071979.
21. Kuriyama S, Watanabe M, Nakamura S, Nishitani K, Sekiguchi K, Tanaka Y, Ito H, Matsuda S. Classical target coronal alignment in high tibial osteotomy demonstrates validity in terms of knee kinematics and kinetics in a computer model. Knee Surg Sports Traumatol Arthrosc. 2020 May;28(5):1568-1578. doi: 10.1007/s00167-019-05575-3. Epub 2019 Jun 21. PMID: 31227865.
22. Ishigooka N, Fujii T, Abe H, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ito H, Ohmura K, Morita S, Mimori T. Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis. Mod Rheumatol. 2020 May;30(3):450-457. doi: 10.1080/14397595.2019.1621439. Epub 2019 Jun 13. PMID: 31116051.
23. Nakabo S, Tsuji Y, Inagaki M, Tsuji H, Nakajima T, Murakami K, Terao C, Hashimoto M, Furu M, Tanaka M, Ito H, Fujii T, Mimori T, Fujii Y. Severe joint deformity and patient global assessment of disease are associated with discrepancies between sonographic and clinical remission: A cross-sectional study of rheumatoid arthritis patients. Mod Rheumatol. 2021 Mar;31(2):334-342. doi: 10.1080/14397595.2020.1751922. Epub 2020 May 5. PMID: 32243209.
24. Nakagami Y, Sugihara G, Nakashima N, Hazama M, Son S, Ma S, Matsumoto R, Murai T, Ikeda A, Murakami K. Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia. Sci Rep. 2020 May 13;10(1):7906. doi: 10.1038/s41598-020-63776-0. PMID: 32404964; PMCID: PMC7220915.
25. Nishitani K, Kuriyama S, Nakamura S, Umatani N, Ito H, Matsuda S. Excessive flexed position of the femoral component was associated with poor new Knee Society Score after total knee arthroplasty with the Bi-Surface knee prosthesis. Bone Joint J. 2020 Jun;102-B(6_Supple_A):36-42. doi: 10.1302/0301-620X.102B6.BJJ-2019-1531.R1. PMID: 32475263.
26. Nishitani K, Ito T, Hatada R, Kuriyama S, Nakamura S, Ito H, Matsuda S. High and Varied Anterior Condyle of the Distal Femur Is Associated with Limited Flexion in Varus Knee Osteoarthritis. Cartilage. 2021 Dec;13(1_suppl):1487S-1493S. doi: 10.1177/1947603520928582. Epub 2020 Jun 4. PMID: 32493051; PMCID: PMC8808831.
27. Iwata T, Ito H, Furu M, Ishikawa M, Azukizawa M, Akiyama H, Matsuda S. Destructive arthritis with cutaneous polyarteritis nodosa requiring surgical intervention: a case report and review of the literature. Mod Rheumatol Case Rep. 2020 Jul;4(2):272-277. doi: 10.1080/24725625.2020.1741071. Epub 2020 Mar 23. PMID: 33087001.
28. Sekiguchi K, Nakamura S, Nakamura K, Ito H, Kuriyama S, Nishitani K, Komistek RD, Matsuda S. Varus alignment after total knee arthroplasty results in greater axial rotation during deep knee bend activity. Clin Biomech (Bristol, Avon). 2020 Jul;77:105051. doi: 10.1016/j.clinbiomech.2020.105051. Epub 2020 May 20. PMID: 32464429.
29. Tsuji H, Hashimoto M, Harada T, Tanaka M, Ito H, Murakami K, Ohmura K, Fujii T, Mimori T. Persistent anemia and hypoalbuminemia in rheumatoid arthritis patients with low serum triiodothyronine level. Mod Rheumatol. 2020 Jul;30(4):640-647. doi: 10.1080/14397595.2019.1649109. Epub 2019 Aug 8. PMID: 31393192.
30. Gon Y, Yoshifuji H, Nakajima T, Murakami K, Nakashima R, Ohmura K, Mimori T, Terao C. Long-term outcomes of refractory Takayasu arteritis patients treated with biologics including ustekinumab. Mod Rheumatol. 2021 May;31(3):678-683. doi: 10.1080/14397595.2020.1800560. Epub 2020 Aug 19. PMID: 32700985.
31. Emori T, Kasahara M, Sugahara S, Hashimoto M, Ito H, Narumiya S, Higashi Y, Fujii Y. Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib. Eur J Pharmacol. 2020 Sep 5;882:173238. doi: 10.1016/j.ejphar.2020.173238. Epub 2020 Jun 16. PMID: 32561292.
32. Okahata A, Ito H, Furu M, Ishikawa M, Fujii T, Hashimoto M, Tanaka M, Morita Y, Azukizawa M, Tomizawa T, Doi K, Nishitani K, Murata K, Yoshitomi H, Mimori T, Matsuda S. Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis. J Clin Rheumatol. 2020 Oct;26(7):295-300. doi: 10.1097/RHU.0000000000001116. PMID: 31397763.
33. Watanabe M, Kuriyama S, Nakamura S, Nishitani K, Tanaka Y, Sekiguchi K, Ito H, Matsuda S. Abnormal knee kinematics caused by mechanical alignment in symmetric bicruciate-retaining total knee arthroplasty are alleviated by kinematic alignment. Knee. 2020 Oct;27(5):1385-1395. doi: 10.1016/j.knee.2020.07.099. Epub 2020 Aug 15. PMID: 33010752.
34. Iwasaki T, Nakabo S, Terao C, Murakami K, Nakashima R, Hashimoto M, Imura Y, Yukawa N, Yoshifuji H, Miura Y, Yurugi K, Maekawa T, van Delft MAM, Trouw LA, Fujii T, Mimori T, Ohmura K. Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency. Arthritis Res Ther. 2020 Oct 19;22(1):248. doi: 10.1186/s13075-020-02351-4. PMID: 33076960; PMCID: PMC7574466.
35. Kawahara R, Nakabo S, Shimizu M, Yamamoto H, Sasai T, Nishida Y, Funakoshi S, Gon Y, Taniguchi M, Nakajima T, Hiwa R, Hashimoto M, Tomizawa T, Azukizawa M, Nishitani K, Murata K, Tanaka M, Ito H, Mimori T, Fujii Y. Feasibility of patient-oriented ultrasound joint selection: Cross-sectional observational study on rheumatoid arthritis. Mod Rheumatol. 2020 Nov;30(6):975-981. doi: 10.1080/14397595.2019.1680095. Epub 2019 Oct 28. PMID: 31612758.
36. Kondo-Ishikawa S, Fujii T, Ishigooka N, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ohmura K, Mimori T. Association of anti-NR2 and U1RNP antibodies with neurotoxic inflammatory mediators in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus. Lupus. 2020 Nov;29(13):1673-1682. doi: 10.1177/0961203320954918. Epub 2020 Sep 3. PMID: 32883159.
37. Yamazaki K, Minatoya K, Sakamoto K, Kitagori K, Okuda M, Murakami K. Hypothermic circulatory arrest for aortic dissection with cryoglobulinemia. J Card Surg. 2020 Nov;35(11):3169-3172. doi: 10.1111/jocs.14908. Epub 2020 Jul 28. PMID: 32725644.
38. Shirakashi M, Nakashima R, Tsuji H, Tanizawa K, Handa T, Hosono Y, Akizuki S, Murakami K, Hashimoto M, Yoshifuji H, Ohmura K, Mimori T. Efficacy of plasma exchange in anti-MDA5-positive dermatomyositis with interstitial lung disease under combined immunosuppressive treatment. Rheumatology (Oxford). 2020 Nov 1;59(11):3284-3292. doi: 10.1093/rheumatology/keaa123. PMID: 32276271.
39. Murata K, Ito H, Hashimoto M, Murakami K, Watanabe R, Tanaka M, Yamamoto W, Matsuda S. Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort. Arthritis Res Ther. 2020 Nov 12;22(1):268. doi: 10.1186/s13075-020-02366-x. PMID: 33183344; PMCID: PMC7664066.
40. Kida D, Takahashi N, Kaneko A, Hirano Y, Fujibayashi T, Kanayama Y, Hanabayashi M, Yabe Y, Takagi H, Oguchi T, Kato T, Funahashi K, Matsumoto T, Ando M, Kuwatsuka Y, Tanaka E, Yasuoka H, Kaneko Y, Hirata S, Murakami K, Sobue Y, Nishiume T, Suzuki M, Yokota Y, Terabe K, Asai S, Ishiguro N, Kojima T. A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients. Sci Rep. 2020 Nov 12;10(1):19717. doi: 10.1038/s41598-020-76842-4. PMID: 33184461; PMCID: PMC7661716.
41. Nigoro K, Ito H, Kawata T, Nishitani K, Tabara Y, Matsuda F, Narumiya S, Matsuda S; Nagahama Study group. Obesity with radiological changes or depression was associated with worse knee outcome in general population: a cluster analysis in the Nagahama study. Arthritis Res Ther. 2020 Nov 27;22(1):280. doi: 10.1186/s13075-020-02375-w. PMID: 33246505; PMCID: PMC7694310.
42. Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S. A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis. Sci Rep. 2020 Nov 27;10(1):20787. doi: 10.1038/s41598-020-77735-2. Erratum in: Sci Rep. 2021 Mar 29;11(1):7442. doi: 10.1038/s41598-021-86883-y. PMID: 33247195; PMCID: PMC7695735.
43. Tanaka Y, Nakamura S, Kuriyama S, Nishitani K, Ito H, Lyman S, Matsuda S. Intraoperative physiological lateral laxity in extension and flexion for varus knees did not affect short-term clinical outcomes and patient satisfaction. Knee Surg Sports Traumatol Arthrosc. 2020 Dec;28(12):3888-3898. doi: 10.1007/s00167-020-05862-4. Epub 2020 Feb 6. PMID: 32030501.
44. Kuriyama S, Watanabe M, Nakamura S, Nishitani K, Tanaka Y, Sekiguchi K, Ito H, Matsuda S. Large medial proximal tibial angles cause excessively medial tibiofemoral contact forces and abnormal knee kinematics following open-wedge high tibial osteotomy. Clin Biomech (Bristol, Avon). 2020 Dec;80:105190. doi: 10.1016/j.clinbiomech.2020.105190. Epub 2020 Oct 1. PMID: 33053468.
45. Nakano K, Tanaka Y, Saito K, Kaneko Y, Saito S, Tanaka M, Saito R, Fujii T, Kuramoto N, Sugimoto N, Takada H, Harigai M, Sasaki S, Suzuki Y. Treatment of rheumatoid arthritis after regression of lymphoproliferative disorders in patients treated with methotrexate: a retrospective, multi-center descriptive study. Mod Rheumatol. 2022 Jan 5;32(1):41-49. doi: 10.1080/14397595.2020.1847775. PMID: 33164614.
46. Tomizawa T, Nishitani K, Ito H, Okae Y, Morita Y, Doi K, Saito M, Ishie S, Yoshida S, Murata K, Yoshitomi H, Kuroda Y, Matsuda S. The limitations of mono- and combination antibiotic therapies on immature biofilms in a murine model of implant-associated osteomyelitis. J Orthop Res. 2021 Feb;39(2):449-457. doi: 10.1002/jor.24956. Epub 2020 Dec 23. PMID: 33325059.
47. Kaneko Y, Kawahito Y, Kojima M, Nakayama T, Hirata S, Kishimoto M, Endo H, Seto Y, Ito H, Nishida K, Matsushita I, Kojima T, Kamatani N, Tsutani K, Igarashi A, Hasegawa M, Miyasaka N, Yamanaka H. Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis. Mod Rheumatol. 2021 Jan;31(1):61-69. doi: 10.1080/14397595.2020.1719607. Epub 2020 Jan 30. PMID: 31960737.
48. Tsuji H, Yoshifuji H, Shindo T, Hishizawa M, Ishida A, Fujimoto M, Kitagori K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Tanaka M, Ohmura K. Primary hepatic lymphoma as other iatrogenic immunodeficiency-related lymphoproliferative disorders: a case report and review of the literature. Mod Rheumatol Case Rep. 2021 Jan;5(1):172-177. doi: 10.1080/24725625.2020.1826627. Epub 2020 Oct 22. PMID: 32985951.
49. Kuramoto N, Saito S, Fujii T, Kaneko Y, Saito R, Tanaka M, Takada H, Nakano K, Saito K, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Characteristics of rheumatoid arthritis with immunodeficiency-associated lymphoproliferative disorders to regress spontaneously by the withdrawal of methotrexate and their clinical course: A retrospective, multicenter, case-control study. Mod Rheumatol. 2022 Jan 5;32(1):24-31. doi: 10.1080/14397595.2021.1879362. PMID: 33496194.
50. Itaya T, Torii M, Hashimoto M, Tanigawa K, Urai Y, Kinoshita A, Nin K, Jindai K, Watanabe R, Murata K, Murakami K, Tanaka M, Ito H, Matsuda S, Morinobu A. Prevalence of anxiety and depression in patients with rheumatoid arthritis before and during the COVID-19 pandemic. Rheumatology (Oxford). 2021 Apr 6;60(4):2023-2024. doi: 10.1093/rheumatology/keab065. PMID: 33502497; PMCID: PMC7928586.
52. Saito R, Tanaka M, Ito H, Kuramoto N, Fujii T, Saito S, Kaneko Y, Nakano K, Saito K, Takada H, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Overall survival and post-spontaneous regression relapse-free survival of patients with lymphoproliferative disorders associated with rheumatoid arthritis: a multi-center retrospective cohort study. Mod Rheumatol. 2022 Jan 5;32(1):50-58. doi: 10.1080/14397595.2020.1866837. PMID: 33336615.

2019年

1. Murata K, Hashimoto M, Yamamoto W, Son Y, Amuro H, Nagai K, Takeuchi T, Katayama M, Maeda Y, Ebina K, Hara R, Jinno S, Onishi A, Murakami K, Tanaka M, Ito H, Mimori T, Matsuda S. The family history of rheumatoid arthritis in anti-cyclic citrullinated peptide antibody-positive patient is not a predictor of poor clinical presentation and treatment response with modern classification criteria and treatment strategy: the ANSWER cohort study. Rheumatol Int. 2019 [Epub ahead of print]
   • 家族歴のあるリウマチ患者さんの予後や治療反応性は、家族歴のない方と比べて必ずしも悪くないことを示しました。
2. Kawahara R, Nakabo S, Shimizu M, Yamamoto H, Sasai T, Nishida Y, Funakoshi S, Gon Y, Taniguchi M, Nakajima T, Hiwa R, Hashimoto M, Tomizawa T, Azukizawa M, Nishitani K, Murata K, Tanaka M, Ito H, Mimori T, Fujii Y. Feasibility of patient-oriented ultrasound joint selection: Cross-sectional observational study on rheumatoid arthritis. Mod Rheumatol. 2019 [Epub ahead of print]
   • 痛みのある関節を選択的に関節エコーで評価することが、リウマチの病勢評価に役に立つことを示しました。
3. Matsuo H, Imamura A, Shimizu M, Inagaki M, Tsuji Y, Nakabo S, Hashimoto M, Ito H, Tanaka S, Mimori T, Fujii Y. Prediction of recurrence and remission using superb microvascular imaging in rheumatoid arthritis. J Med Ultrason (2001). 2019 [Epub ahead of print]
   • 関節エコーによる微細な血流評価で、寛解からの再発を予測できることを示しました
4. Ishikawa Y, Ikari K, Hashimoto M, Ohmura K, Tanaka M, Ito H, Taniguchi A, Yamanaka H, Mimori T, Terao C. Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor. Ann Rheum Dis. 2019 Nov;78(11):1480-1487. doi: 10.1136/annrheumdis-2019-215463. Epub 2019 Aug 19.
   • リウマチにかかわる抗CCP抗体価は、特定の遺伝因子と喫煙量の影響を受けることを示しました。
5. Okahata A, Ito H, Furu M, Ishikawa M, Fujii T, Hashimoto M, Tanaka M, Morita Y, Azukizawa M, Tomizawa T, Doi K, Nishitani K, Murata K, Yoshitomi H, Mimori T, Matsuda S. Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis. J Clin Rheumatol. 2019 Aug 6. doi: 10.1097/RHU.0000000000001116. [Epub ahead of print]
   • 血清マーカーのsLOX1により、関節リウマチのリウマトイド因子の変化を予測しうることを示しました。
6. Tsuji H, Hashimoto M, Harada T, Tanaka M, Ito H, Murakami K, Ohmura K, Fujii T, Mimori T. Persistent anemia and hypoalbuminemia in rheumatoid arthritis patients with low serum triiodothyronine level. Mod Rheumatol. 2019 Aug 8:1-8. doi: 10.1080/14397595.2019.1649109. [Epub ahead of print]
   • 甲状腺機能検査のfT3値が低いリウマチ患者さんは、貧血や低アルブミン血症が遷延しやすいことを示しました。
7. Sasaki C, Hiraishi T, Oku T, Okuma K, Suzumura K, Hashimoto M, Ito H, Aramori I, Hirayama Y. Metabolomic approach to the exploration of biomarkers associated with disease activity in rheumatoid arthritis. PLoS One. 2019 Jul 11;14(7):e0219400. doi: 10.1371/journal.pone.0219400. eCollection 2019.
   • リウマチの病気の勢いに関連のある代謝関連マーカーを網羅的に探索しました。
8. Iwamoto N, Takanashi M, Yokoyama K, Yonezawa A, Denda M, Hashimoto M, Tanaka M, Ito H, Matsuura M, Yamamoto S, Honzawa Y, Matsubara K, Shimada T. Multiplexed monitoring of therapeutic antibodies for inflammatory diseases using Fab-selective proteolysis nSMOL coupled with LC-MS. J Immunol Methods. 2019 Sep;472:44-54. doi: 10.1016/j.jim.2019.06.014. Epub 2019 Jun 12.
   • リウマチの治療に使われている生物学的製剤の血中濃度を、質量分析により一斉に測定する技術を確立しました。
9. Ishigooka N, Fujii T, Abe H, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ito H, Ohmura K, Morita S, Mimori T. Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis. Mod Rheumatol. 2019 [Epub ahead of print]
   • リウマチにかかわる抗シトルリン化蛋白抗体が消失する患者さんの臨床的な特徴を明らかにしました。
10. Yamamoto H, Nakajima T, Kawahara R, Nakabo S, Hashimoto M, Yamamoto W, Masuda I, Ito H, Mimori T, Fujii Y. Evaluation of risk factors for atherosclerosis using carotid ultrasonography in Japanese patients with rheumatoid arthritis. Int J Rheum Dis. 2019 Jul;22(7):1312-1318.
    • 頸動脈エコー検査により、日本人のリウマチ患者さんの動脈硬化にかかわるリスク因子を明らかにしました。
11. Ishikawa Y, Hashimoto M, Ito H, Tanaka M, Yukawa N, Fujii T, Yamamoto W, Mimori T, Terao C. Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis. Semin Arthritis Rheum. 2019;49(2):204-210.
    • 生物学的製剤に対する治療反応性がよくない患者さんでは、治療後に抗核抗体が上昇しやすいことを示しました。
12. Murata K, Ito H, Hashimoto M, Nishitani K, Murakami K, Tanaka M, Yamamoto W, Mimori T, Matsuda S. Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort. Int J Rheum Dis. 2019;22(6):1084-1093.
    • 高齢で発症したリウマチ患者さんは、薬はよく効くけれども骨破壊がすすみやすいことを示しました
13. Doi K, Ito H, Tomizawa T, Murata K, Hashimoto M, Tanaka M, Murakami K, Nishitani K, Azukizawa M, Okahata A, Saito M, Mimori T, Matsuda S. Oral steroid decreases the progression of joint destruction of large joints in the lower extremities in rheumatoid arthritis. Medicine (Baltimore) 2019;98(47):e17968.
    • 経口ステロイドは、大きな関節の破壊進行予防には有効な場合があることを示しました。
14. Tomizawa T, Ito H, Murata K, Hashimoto M, Tanaka M, Murakami K, Nishitani K, Azukizawa M, Okahata A, Doi K, Saito M, Furu M, Hamaguchi M, Mimori T, Matsuda S. Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis. Arthritis Res Ther 2019 July 15;21(1):174.
    • リウマチ患者さんにおいて骨密度は、部分ごとに進行が異なり、バイオマーカーもそれぞれ異なることを示しました。
15. Nakagami Y, Sugihara G, Takei N, Fujii T, Hashimoto M, Murakami K, Furu M, Ito H, Uda M, Torii M, Nin K, Murai T, Mimori T. Effect of physical state on pain mediated through emotional health in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2019 Sep;71(9):1216-1223.
    • リウマチ患者さんの痛みには、関節の腫れや炎症だけでなく、精神状態も影響することを示しました
16. Torii M, Hashimoto M, Hanai A, Fujii T, Furu M, Ito H, Uozumi R, Hamaguchi M, Terao C, Yamamoto W, Uda M, Nin K, Morita S, Arai H, Mimori T. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Mod Rheumatol 2019 Jul;29(4):589-595.
    • リウマチ患者さんは健常者に比べてサルコペニア（加齢に伴う筋量や筋力の低下）を合併しやすく、転倒や骨折のリスクになっていることを示しました
17. Azukizawa M, Ito H, Hamamoto Y, Fujii T, Morita Y, Okahata A, Tomizawa T, Furu M, Nishitani K, Kuriyama S, Nakamura S, Yoshitomi H, Nakatani T, Tsuboyama T, Hamaguchi M, Matsuda S, Yasuda T. The Effects of Well-Rounded Exercise Program on Systemic Biomarkers Related to Cartilage Metabolism. Cartilage. 2019 Oct;10(4):451-458. doi: 10.1177/1947603518767998. Epub 2018 Apr 12. PMID: 29644876; PMCID: PMC6755879.
18. Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M, Onishi A, Nagai K, Son Y, Amuro H, Yamamoto K, Maeda Y, Murata K, Jinno S, Takeuchi T, Hirao M, Kumanogoh A, Yoshikawa H. Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study. Arthritis Res Ther. 2019 Apr 11;21(1):91. doi: 10.1186/s13075-019-1880-4. Erratum in: Arthritis Res Ther. 2019 May 6;21(1):114. doi: 10.1186/s13075-019-1897-8. PMID: 30971306; PMCID: PMC6458752.
19. Gu S, Kuriyama S, Nakamura S, Nishitani K, Ito H, Matsuda S. Underhang of the tibial component increases tibial bone resorption after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2019 Apr;27(4):1270-1279. doi: 10.1007/s00167-018-5309-4. Epub 2018 Nov 23. PMID: 30470851.
20. Ito H, Tominari S, Tabara Y, Nakayama T, Furu M, Kawata T, Azukizawa M, Setoh K, Kawaguchi T, Matsuda F, Matsuda S; Nagahama Study group. Low back pain precedes the development of new knee pain in the elderly population; a novel predictive score from a longitudinal cohort study. Arthritis Res Ther. 2019 Apr 15;21(1):98. doi: 10.1186/s13075-019-1884-0. PMID: 30987680; PMCID: PMC6466785.
21. Ito H, Tsuji S, Nakayama M, Mochida Y, Nishida K, Ishikawa H, Kojima T, Matsumoto T, Kubota A, Mochizuki T, Sakuraba K, Matsushita I, Nakajima A, Hara R, Haraguchi A, Matsubara T, Kanbe K, Nakagawa N, Hamaguchi M, Momohara S; JOSRA Consortium. Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs? J Rheumatol. 2020 Apr;47(4):502-509. doi: 10.3899/jrheum.181100. Epub 2019 Jun 15. PMID: 31203226.
22. Kaneko Y, Kawahito Y, Kojima M, Nakayama T, Hirata S, Kishimoto M, Endo H, Seto Y, Ito H, Nishida K, Matsushita I, Kojima T, Kamatani N, Tsutani K, Igarashi A, Hasegawa M, Miyasaka N, Yamanaka H. Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis. Mod Rheumatol. 2021 Jan;31(1):61-69. doi: 10.1080/14397595.2020.1719607. Epub 2020 Jan 30. PMID: 31960737.
23. Kuriyama S, Morimoto N, Shimoto T, Takemoto M, Nakamura S, Nishitani K, Ito H, Matsuda S, Higaki H. Clinical efficacy of preoperative 3D planning for reducing surgical errors during open-wedge high tibial osteotomy. J Orthop Res. 2019 Apr;37(4):898-907. doi: 10.1002/jor.24263. Epub 2019 Mar 21. PMID: 30816588.
24. Kuriyama S, Watanabe M, Nakamura S, Nishitani K, Sekiguchi K, Tanaka Y, Ito H, Matsuda S. Classical target coronal alignment in high tibial osteotomy demonstrates validity in terms of knee kinematics and kinetics in a computer model. Knee Surg Sports Traumatol Arthrosc. 2020 May;28(5):1568-1578. doi: 10.1007/s00167-019-05575-3. Epub 2019 Jun 21. PMID: 31227865.
25. Masamoto K, Fujibayashi S, Otsuki B, Hara K, Fukushima Y, Koizumi K, Shimizu T, Shimizu Y, Morizane K, Murata K, Matsuda S. Utility of Thoracolumbar Low-Dose CT With Model-Based Iterative Reconstruction for Measuring Pedicle Diameter Using a Radiation Dose Less Than a One-Time Lumbar X-Ray. Spine (Phila Pa 1976). 2020 Jan 1;45(1):38-47. doi: 10.1097/BRS.0000000000003210. PMID: 31425432.
26. Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD Jr, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G. Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Res. 2019 Jul 15;7:20. doi: 10.1038/s41413-019-0061-z. PMID: 31646012; PMCID: PMC6804538.
27. Matsuo T, Hashimoto M, Ito I, Kubo T, Uozumi R, Furu M, Ito H, Fujii T, Tanaka M, Terao C, Kono H, Mori M, Hamaguchi M, Yamamoto W, Ohmura K, Morita S, Mimori T. Interleukin-18 is associated with the presence of interstitial lung disease in rheumatoid arthritis: a cross-sectional study. Scand J Rheumatol. 2019 Mar;48(2):87-94. doi: 10.1080/03009742.2018.1477989. Epub 2018 Sep 30. PMID: 30269670.
28. Matsuo T, Hashimoto M, Sakaguchi S, Sakaguchi N, Ito Y, Hikida M, Tsuruyama T, Sakai K, Yokoi H, Shirakashi M, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Fujii T, Mimori T. Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation. J Immunol. 2019 Jun 1;202(11):3161-3172. doi: 10.4049/jimmunol.1801159. Epub 2019 Apr 24. PMID: 31019063.
29. Morizane K, Takemoto M, Neo M, Fujibayashi S, Otsuki B, Tanida S, Shimizu T, Ito H, Matsuda S. Occipital and external acoustic meatus to axis angle: a useful predictor of oropharyngeal space in rheumatoid arthritis patients with atlantoaxial subluxation. J Neurosurg Spine. 2019 Jun 21;31(4):534-541. doi: 10.3171/2019.3.SPINE181390. PMID: 31226680.
30. Murakami I, Murakami K, Hashimoto M, Tanaka M, Ito H, Fujii T, Torii M, Ikeda K, Kuwabara A, Tanaka K, Yoshida A, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Usui T, Morita S, Mimori T. Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis. PLoS One. 2020 Feb 13;15(2):e0228852. doi: 10.1371/journal.pone.0228852. PMID: 32053642; PMCID: PMC7018088.
31. Nagae K, Asao Y, Sudo Y, Murayama N, Tanaka Y, Ohira K, Ishida Y, Otsuka A, Matsumoto Y, Saito S, Furu M, Murata K, Sekiguchi H, Kataoka M, Yoshikawa A, Ishii T, Togashi K, Shiina T, Kabashima K, Toi M, Yagi T. Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs. F1000Res. 2018 Nov 19;7:1813. doi: 10.12688/f1000research.16743.2. PMID: 30854189; PMCID: PMC6396844.
32. Nakabo S, Ohmura K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Mimori T. Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis. Mod Rheumatol. 2020 Mar;30(2):345-349. doi: 10.1080/14397595.2019.1583819. Epub 2019 May 2. PMID: 30789095.
33. Nakamura S, Shima K, Kuriyama S, Nishitani K, Ito H, Matsuda S. Tibial Tubercle-Trochlear Groove Distance Influences Patellar Tilt After Total Knee Arthroplasty. J Arthroplasty. 2019 Dec;34(12):3080-3087. doi: 10.1016/j.arth.2019.07.038. Epub 2019 Aug 1. PMID: 31451393.
34. Nakamura T, Satoh-Nakamura T, Nakajima A, Kawanami T, Sakai T, Fujita Y, Iwao H, Miki M, Masaki Y, Okazaki T, Ishigaki Y, Kawano M, Yamada K, Matsui S, Saeki T, Kamisawa T, Yamamoto M, Hamano H, Origuchi T, Hirata S, Tanaka Y, Tsuboi H, Sumida T, Okazaki K, Tanaka M, Chiba T, Mimori T, Umehara H. Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD. Mod Rheumatol. 2020 May;30(3):551-557. doi: 10.1080/14397595.2019.1621475. Epub 2019 Jul 11. PMID: 31116057.
35. Nishitani K, Hatada R, Kuriyama S, Lyman SL, Nakamura S, Ito H, Matsuda S. A greater reduction in the distal femoral anterior condyle improves flexion after total knee arthroplasty in patients with osteoarthritis. Knee. 2019 Dec;26(6):1364-1371. doi: 10.1016/j.knee.2019.09.002. Epub 2019 Oct 22. PMID: 31653442.
36. Nishitani K, Kuriyama S, Nakamura S, Ito H, Matsuda S. A Multivariate Analysis on the Effect of No Closed Suction Drain on the Length of Hospital Stay in Total Knee Arthroplasty. Knee Surg Relat Res. 2019 Mar 1;31(1):25-30. doi: 10.5792/ksrr.18.013. PMID: 30871289; PMCID: PMC6425893.
37. Nishitani K, Kuriyama S, Nakamura S, Morita Y, Ito H, Matsuda S. Valgus position of the femoral component causes abnormal kinematics in the presence of medial looseness in total knee arthroplasty: a computer simulation model of TKA for valgus knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2051-2060. doi: 10.1007/s00167-018-5264-0. Epub 2018 Oct 29. PMID: 30374567.
38. Nishitani K, Yamamoto Y, Furu M, Kuriyama S, Nakamura S, Ito H, Fukuhara S, Matsuda S. The minimum clinically important difference for the Japanese version of the new Knee Society Score (2011KSS) after total knee arthroplasty. J Orthop Sci. 2019 Nov;24(6):1053-1057. doi: 10.1016/j.jos.2019.09.001. Epub 2019 Sep 19. PMID: 31543424.
39. Sekiguchi K, Nakamura S, Kuriyama S, Nishitani K, Ito H, Tanaka Y, Watanabe M, Matsuda S. Effect of tibial component alignment on knee kinematics and ligament tension in medial unicompartmental knee arthroplasty. Bone Joint Res. 2019 Apr 2;8(3):126-135. doi: 10.1302/2046-3758.83.BJR-2018-0208.R2. PMID: 30997038; PMCID: PMC6444020.
40. Tanaka Y, Nakamura S, Kuriyama S, Nishitani K, Ito H, Lyman S, Matsuda S. Intraoperative physiological lateral laxity in extension and flexion for varus knees did not affect short-term clinical outcomes and patient satisfaction. Knee Surg Sports Traumatol Arthrosc. 2020 Dec;28(12):3888-3898. doi: 10.1007/s00167-020-05862-4. Epub 2020 Feb 6. PMID: 32030501.
41. Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K. Biofilm Producing Staphylococcus epidermidis (RP62A Strain) Inhibits Osseous Integration Without Osteolysis and Histopathology in a Murine Septic Implant Model. J Orthop Res. 2020 Apr;38(4):852-860. doi: 10.1002/jor.24512. Epub 2019 Nov 19. PMID: 31692081; PMCID: PMC7071979.
42. Tsuji H, Ikari K, Ohmura K, Yano K, Furu M, Hashimoto M, Ito H, Fujii T, Yamamoto W, Taniguchi A, Yamanaka H, Mimori T, Terao C. Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis. Ann Rheum Dis. 2019 Feb;78(2):284-286. doi: 10.1136/annrheumdis-2018-214022. Epub 2018 Sep 19. PMID: 30232193.
43. Tsuji H, Nakashima R, Hosono Y, Imura Y, Yagita M, Yoshifuji H, Hirata S, Nojima T, Sugiyama E, Hatta K, Taguchi Y, Katayama M, Tanizawa K, Handa T, Uozumi R, Akizuki S, Murakami K, Hashimoto M, Tanaka M, Ohmura K, Mimori T. Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis. Arthritis Rheumatol. 2020 Mar;72(3):488-498. doi: 10.1002/art.41105. Epub 2020 Jan 27. PMID: 31524333.
44. Watanabe M, Kuriyama S, Nakamura S, Nishitani K, Tanaka Y, Sekiguchi K, Ito H, Matsuda S. Impact of intraoperative adjustment method for increased flexion gap on knee kinematics after posterior cruciate ligament-sacrificing total knee arthroplasty. Clin Biomech (Bristol, Avon). 2019 Mar;63:85-94. doi: 10.1016/j.clinbiomech.2019.02.018. Epub 2019 Feb 27. PMID: 30851566.

2018年

1. Murata K, Ito H, Hashimoto M, Nishitani K, Murakami K, Tanaka M, Yamamoto W, Mimori T, Matsuda S.　Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort.　Int J Rheum Dis. 2018 [Epub ahead of print]
   • 高齢で発症したリウマチ患者さんは、薬はよく効くけれども骨破壊がすすみやすいことを示しました
2. Nakagawa S, Nakaishi M, Hashimoto M, Ito H, Yamamoto W, Nakashima R, Tanaka M, Fujii T, Omura T, Imai S, Nakagawa T, Yonezawa A, Imai H, Mimori T, Matsubara K.　 Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis.　PLoS One. 2018;13(11):e0206943.
   • 薬剤の薬をきちんと服用する患者さんは服用しない患者さんに比べて、リウマチが悪化しにくいことを示しました
3. Nakagami Y, Sugihara G, Takei N, Fujii T, Hashimoto M, Murakami K, Furu M, Ito H, Uda M, Torii M, Nin K, Murai T, Mimori T.　 Effect of physical state on pain mediated through emotional health in rheumatoid arthritis.　Arthritis Care Res (Hoboken). 2018.. [Epub ahead of print]
   • リウマチ患者さんの痛みには、関節の腫れや炎症だけでなく、精神状態も影響することを示しました
4. Tsuji H, Ikari K, Ohmura K, Yano K, Furu M, Hashimoto M, Ito H, Fujii T, Yamamoto W, Taniguchi A, Yamanaka H, Mimori T, Terao C.　 Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis.　Ann Rheum Dis. 2018 [Epub ahead of print]
   • HLA-DRB1*04:05という遺伝子をもっているリウマチ患者さんは、関節の腫れに関係なく骨破壊が進みやすいことを示しました
5. Torii M, Hashimoto M, Hanai A, Fujii T, Furu M, Ito H, Uozumi R, Hamaguchi M, Terao C, Yamamoto W, Uda M, Nin K, Morita S, Arai H, Mimori T.　Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Mod Rheumatol. 2018 [Epub ahead of print]
   • リウマチ患者さんは健常者に比べてサルコペニア（加齢に伴う筋量や筋力の低下）を合併しやすく、転倒や骨折のリスクになっていることを示しました
6. Hashimoto M, Furu M, Yamamoto W, Fujimura T, Hara R, Katayama M, Ohnishi A, Akashi K, Yoshida S, Nagai K, Son Y, Amuro H, Hirano T, Ebina K, Uozumi R, Ito H, Tanaka M, Ohmura K, Fujii T, Mimori T. Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study. Arthritis Res Ther. 2018;20(1):165.
   • 長期間、深い寛解を達成した後、ステロイドが要らない状態で生物学的製剤を休薬すると、休薬後もリウマチの再燃が少ないことを示しました
7. Yoshida T, Hashimoto M, Kawahara R, Yamamoto H, Tanaka M, Ito H, Masuda I, Hosoda K, Yamamoto W, Uozumi R, Morita S, Fujii Y, Mimori T, Nin K. Non-obese visceral adiposity is associated with the risk of atherosclerosis in Japanese patients with rheumatoid arthritis: a cross-sectional study. Rheumatol Int. 2018;38(9):1679-1689.
   • リウマチ患者さんは、正常体重でも内臓脂肪の割合が高い（サルコペニア肥満）人が多く、そのような患者さんは動脈硬化のリスクが高いことを示しました
8. Ito H, Moritoshi F, Hashimoto M, Tanaka M, Matsuda S. Control of articular synovitis for bone and cartilage regeneration in rheumatoid arthritis. Inflamm Regen. 2018;38:7.
   • リウマチの関節破壊の進行を止めるためには、寛解を達成するだけでなく維持することが重要であることを示しました
9. Morita Y, Ito H, Torii M, Hanai A, Furu M, Hashimoto M, Tanaka M, Azukizawa M, Arai H, Mimori T, Matsuda S. Factors affecting walking ability in female patients with rheumatoid arthritis. PLoS One. 2018;13(3):e0195059.
   • リウマチ患者さんの歩行には、膝を伸ばす力とリウマチのコントロールが重要であることを示しました
10. Ebina K, Hashimoto M, Yamamoto W, Ohnishi A, Kabata D, Hirano T, Hara R, Katayama M, Yoshida S, Nagai K, Son Y, Amuro H, Akashi K, Fujimura T, Hirao M, Yamamoto K, Shintani A, Kumanogoh A, Yoshikawa H. Drug retention and discontinuation reasons between seven biologics in patients with rheumatoid arthritis -The ANSWER cohort study. PLoS One. 2018;13(3):e0194130.
    • 7種類の生物学的製剤の継続率とその中止理由を、KURAMAコホートを含む関西の多施設ANSWERコホートで検討しました
11. Nishitani K, Ito H, Shimozono Y, Furu M, Azukizawa M, Hashimoto M, Tanaka M, Mimori T, Matsuda S. Correlation in the Coronal Angle between Knee and Hindfoot Was Observed in Patients with Rheumatoid Arthritis Unless Talocrural Joint Was Destroyed. Biomed Res Int. 2017;2017:4051706.
    • リウマチ患者さんは膝が悪くなって変形しても足の関節でその変形を補っているが、足の関節も破壊されると代償しきれなくなることを示しました
12. Masamoto K, Otsuki B, Fujibayashi S, Shima K, Ito H, Furu M, Hashimoto M, Tanaka M, Lyman S, Yoshitomi H, Tanida S, Mimori T, Matsuda S. Factors influencing spinal sagittal balance, bone mineral density, and Oswestry Disability Index outcome measures in patients with rheumatoid arthritis. Eur Spine J. 2018;27(2):406-415.
    • リウマチ患者さんの背骨の変形には、リウマチの病気の勢いや治療内容、骨粗鬆症などが関係していることを示しました
13. Emori T, Hirose J, Ise K, Yomoda JI, Kasahara M, Shinkuma T, Yoshitomi H, Ito H, Hashimoto M, Sugahara S, Fujita H, Yamamoto N, Morita Y, Narumiya S, Aramori I. Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. J Immunol. 2017;199(10):3427-3436.
    • リウマチ患者さんの滑膜の重層化にインテグリンα9が関係していることを示しました

2017年

1. Kuramoto N, Ohmura K, Ikari K, Yano K, Furu M, Yamakawa N, Hashimoto M, Ito H, Fujii T, Murakami K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T, Terao C. Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis. Sci Rep. 2017 ;7(1):6911.
   • 抗セントロメア抗体が陽性のリウマチ患者さんは、抗核抗体価が高く高齢女性に多いなど特徴的な所見をもつことを示しました
2. Tsuji H, Yano K, Furu M, Yamakawa N, Ikari K, Hashimoto M, Ito H, Fujii T, Yamamoto W, Ohmura K, Taniguchi A, Momohara S, Matsuda F, Allaart CF, Yamanaka H, Mimori T, Terao C. Time-averaged disease activity fits better joint destruction in rheumatoid arthritis. Sci Rep. 2017 ;7(1):5856.
   • レントゲン上の骨破壊は、1回だけの病気の勢いよりも全受診日の平均の病気の勢いとよく相関することを示しました
3. Nakabo S, Yoshifuji H, Hashimoto M, Imura Y, Nakashima R, Murakami K, Kuramoto N, Ito S, Satoh J, Tanaka M, Fujii T, Mimori T, Ohmura K. Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases. J Rheumatol. 2017;44(9):1384-1388.
   • 抗カルバミル化蛋白抗体は関節リウマチだけでなく種々の膠原病にも検出されることを示しました
4. Nakabo S, Hashimoto M, Ito S, Furu M, Ito H, Fujii T, Yoshifuji H, Imura Y, Nakashima R, Murakami K, Kuramoto N, Tanaka M, Satoh J, Ishigami A, Morita S, Mimori T, Ohmura K. Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies. Rheumatology (Oxford). 2017;56(7):1217-1226.
   • リウマチ患者さんの一部に検出される抗カルバミル化蛋白質抗体の標的の一つがアルブミンであることを示しました
5. Hiwa R, Ohmura K, Nakabo S, Terao C, Murakami K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Hashimoto M, Furu M, Ito H, Fujii T, Mimori T. Only rheumatoid factor-positive subset of anti-citrullinated peptide/protein antibody-negative rheumatoid arthritis may seroconvert to anti-citrullinated peptide/protein antibody-positive. Int J Rheum Dis. 2017 ;20(6):731-736.
   • 関節リウマチの診断に有用な抗CCP抗体は，当初陰性の人でも約5%が経過中に陽性に転じる事を明らかにしました

2016年

Iguchi-Hashimoto M, Hashimoto M, Fujii T, Hamaguchi M, Furu M, Ishikawa M, Ito H, Yamakawa N, Terao C, Yamamoto K, Yamamoto W, Ohmura K, Mimori T. The association between serious infection and disease outcome in patients with rheumatoid arthritis.　Clin Rheumatol. 2016; 35(1): 213-8. 入院感染症の既往のあるリウマチ患者さんでは、関節破壊や身体機能障害が進みやすいことを示しました。 Yaku A, Hashimoto M, Furu M, Ito H, Yamakawa N, Yamamoto W, Fujii T, Matsuda F, Mimori T, Terao C. Relationship between handedness and joint involvement in rheumatoid arthritis. Sci Rep. 2016; 6: 39180. リウマチ患者さんの関節破壊は、利き手のほうが進みやすいことを示しました。 Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S. Bone-protective Functions of Netrin 1 Protein. J Biol Chem. 2016; 291(46): 23854-23868. リウマチ患者さんの関節液中に検出されるNetrin-1に骨破壊から保護する働きがあることを示しました。 Ishikawa Y, Fujii T, Ishikawa SK, Yukawa N, Hashimoto M, Furu M, Ito H, Ohmura K, Mimori T. Immunogenicity and Lupus-Like Autoantibody Production Can Be Linked to Each Other along With Type I Interferon Production in Patients with Rheumatoid Arthritis Treated With Infliximab: A Retrospective Study of a Single Center Cohort. PLoS One. 2016; 11(9): e0162896. TNF阻害薬を投与された患者さんで免疫原性や自己抗体反応が起こる場合には、1型インターフェロンが関与していることを示しました。 Mori M, Hashimoto M, Matsuo T, Fujii T, Furu M, Ito H, Yoshitomi H, Hirose J, Ito Y, Akizuki S, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Mimori T. Cell-contact-dependent activation of CD4+ T cells by adhesion molecules on synovial fibroblasts. Mod Rheumatol. 2016 [Epub ahead of print] リウマチ患者さんの滑膜細胞と接触することで、免疫にかかわるCD4T細胞が活性化することを示しました。 Ishikawa M, Ito H, Furu M, Hashimoto M, Fujii T, Okahata A, Mimori T, Matsuda S. Plasma sLOX-1 is a potent biomarker of clinical remission and disease activity in patients with seropositive RA. Mod Rheumatol. 2016; 26(5): 696-701. 血清中のsLOX-1が、関節リウマチ患者さんの寛解や疾患活動性の指標となることを示しました。 Terao C, Ikari K, Nakayamada S, Takahashi Y, Yamada R, Ohmura K, Hashimoto M, Furu M, Ito H, Fujii T, Yoshida S, Saito K, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A twin study of rheumatoid arthritis in the Japanese population. Mod Rheumatol. 2016; 26(5): 685-9. 日本人の双子の研究で、リウマチ発症への遺伝因子の寄与率は57～60%であることを示しました。

2015年

Ishikawa M, Ito H, Furu M, Hashimoto M, Fujii T, Okahata A, Mimori T, Matsuda S. Plasma sLOX-1 is a potent biomarker of clinical remission and disease activity in patients with seropositive RA Modern Rheumatol.2015.In Press. リウマチ患者さんの寛解や活動性の評価に、sLOX-1というマーカーが役に立つことを示しました。 Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S. Systemic effects of surgical intervention on disease activity, daily function and medication in patients with rheumatoid arthritis. Scand J Rheumatol. 2015. In Press. リウマチの外科手術が、その後のリウマチの活動性や日常生活、投薬内容に与える影響を明らかにしました。 Hamamoto Y, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Iwata T, Mimori T, Matsuda S. Serological and Progression Differences of Joint Destruction in the Wrist and the Feet in Rheumatoid Arthritis – A Cross-Sectional Cohort Study. PLoS One. 2015 ;10(8): e0136611. リウマチ患者さんの手と足では、異なった関節破壊の進行の仕方をすることを明らかにしました。 Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H, Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA. Arthritis Rheumatol 2015 67(7): 1744-50. 抗CCP抗体陽性のリウマチ患者さんの関節破壊に、HLAに関する遺伝子が深く関わっていることを示しました。 Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S. Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis. Osteoporosis International 2015 In Press. リウマチの早期にみられる関節周囲の骨粗鬆症の程度が、その後の関節破壊や機能障害と相関することを明らかにしました。 Terao C, Yamakawa N, Yano K, Markusse I, Ikari K, Yoshida S, Furu M, Hashimoto M,  Ito H, Fujii T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart C, Yamanaka H, Mimori T. Matsuda F. Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis. Arthritis and Rheumaology 2015; 67(12): 3113-23. リウマチ因子の有無によって、手指の中で関節破壊が起こりやすい場所が異なることを明らかにしました。 Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, Nishina N, Suzuki A, Myouzen K, Kawaguchi T, Takahashi M, Takasugi K, Murasawa A, Mizuki S, Iwahashi M, Funahashi K, Natsumeda M, Furu M, Hashimoto M, Ito H, Fujii T, Ezawa K, Matsubara T, Takeuchi T, Kubo M, Yamada R, Taniguchi A, Yamanaka H, Momohara S, Yamamoto K, Mimori T, Matsuda F. Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population.Arthritis Res Ther. 2015; 17: 104. 抗CCP抗体陰性と陽性の患者さんの間に、たくさんの遺伝的な共通点があることを示しました。 Hashimoto M, Yamazaki T, Hamaguchi M, Morimoto T, Yamori M, Asai K, Isobe Y, Furu M, Ito H, Fujii T, Terao C, Mori M, Matsuo T, Yoshitomi H, Yamamoto K, Yamamoto W, Bessho K, Mimori T. Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients. PLoS One. 2015; 10: e0122121. 歯周病のある関節痛の患者さんは、歯周病のない患者さんと比べて、その後リウマチを発症する可能性が高くなることを示しました。 Nishiguchi S, Ito H, Yamada M, Yoshitomi H, Furu M, Ito T, Shinohara A, Ura T, Okamoto K, Aoyama T, Tsuboyama T. Self-assessment of rheumatoid arthritis disease activity using a smartphone application: Development and 3-month feasibility study. Methods of Information in Medicine 2015; Sep 22: 54(6). スマートフォンを用いたリウマチの自己評価アプリが、客観的な病気の勢いとよく相関することを示しました。

2014年

Terao C, Hashimoto M, Furu M, Nakabo S, Ohmura K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Matsuda F, Ito H, Fujii T, Mimori T. Inverse association between air pressure and rheumatoid arthritis synovitis. PLoS One 2014; 9: e85376. 気象統計のうちの「気圧」と、リウマチ患者さんの関節症状との間に負の相関がある（気圧が低くなると関節症状が悪化する）ことを示しました。 ※詳しくは、活動案内⇒研究成果ページをご覧ください。 Hashimoto M, Fujii T, Hamaguchi M, Furu M, Ito H, Terao C, Yamamoto K, Yamamoto W, Matsuo T, Mori M, Ohmura K, Kawabata H, Mimori T. Increase of hemoglobin levels by anti-IL-6 receptor antibody (tocilizumab) in rheumatoid arthritis. PLoS One 2014; 9: e98202. 貧血を有するリウマチ患者さんでは、アクテムラを使用するとヘモグロビン値が増加することを示しました。 Furu M, Hashimoto M, Ito H, Fujii T, Terao C, Yamakawa N, Yoshitomi H, Ogino H, Ishikawa M, Matsuda S, Mimori T. Discordance and accordance between patient’s and physician’s assessments in rheumatoid arthritis. Scand J Rheumatol 2014;43:291-5. 医師と患者さんのリウマチの評価が乖離する原因を明らかにしました。（医師は血液検査や関節の腫れを重視し、患者は痛みや身体機能障害を重視） Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignari DAA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S. Detection of  T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 2014; 346: 363-8. リウマチの原因となる免疫細胞（T細胞）が標的とするタンパク質を動物モデルを用いて同定し、それに対する免疫反応がリウマチ患者さんの17％にみられることを示しました。 ※詳しくは、活動案内⇒研究成果ページをご覧ください。 Nishiguchi S, Ito H, Yamada M, Yoshitomi H, Furu M, Ito T, Shinohara A, Ura T, Okamoto K, Aoyama T. Self-assessment tool of disease activity of rheumatoid arthritis by using a smartphone application: a pilot study. Telemed E-health 2014; 20: 235-40. スマートホンを用いて、リウマチの状態を自己評価するアプリケーションを開発しました。

2013年

Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T. Three groups in the 28 joints for rheumatoid arthritis synovitis–Analysis using more than 17,000 assessments in the KURAMA database–, PLoS One. 2013; 8(3): e59341. リウマチ患者さんの関節の腫れ方が、3つの特徴的なパターンに分けられることを明らかにしました。 Murata K, Furu M, Yoshitomi H, Ishikawa M, Shibuya H, Hashimoto M, Imura Y, Fujii T, Ito H, Mimori T, Matsuda S. Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. PLOS ONE 2013 Jul 18; 8(7): e69118. リウマチ患者さんの血液に特徴的に検出されるmicroRNAのパターンを明らかにしました。